Identification of Adipsin as a Novel Prognostic Biomarker in Patients With Coronary Artery Disease.
atherosclerosis
biomarker
coronary artery disease
prognosis
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
8
1
2021
Statut:
ppublish
Résumé
Background Circulating proteins are exposed to vascular endothelial layer and influence their functions. Among them, adipsin is a member of the trypsin family of peptidases and is mainly secreted from adipocytes, monocytes, and macrophages, catalyzing the rate-limiting step of the alternative complement pathway. However, its pathophysiological role in cardiovascular disease remains to be elucidated. Here, we examined whether serum adipsin levels have a prognostic impact in patients with coronary artery disease. Methods and Results In 370 consecutive patients undergoing diagnostic coronary angiography, we performed a cytokine array analysis for screening serum levels of 50 cytokines/chemokines and growth factors. Among them, classification and regression analysis identified adipsin as the best biomarker for prediction of their long-term prognosis (median 71 months; interquartile range, 55-81 months). Kaplan-Meier curve showed that higher adipsin levels (≥400 ng/mL) were significantly associated with all-cause death (hazard ratio [HR], 4.2; 95% CI, 1.7-10.6 [
Identifiants
pubmed: 31752640
doi: 10.1161/JAHA.119.013716
pmc: PMC6912964
doi:
Substances chimiques
Biomarkers
0
CFD protein, human
EC 3.4.21.46
Complement Factor D
EC 3.4.21.46
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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