Aortic Stenosis and Cardiac Amyloidosis: JACC Review Topic of the Week.
Doppler echocardiography
aortic stenosis
cardiac amyloidosis
heart failure
surgical aortic valve replacement
tafamidis
transcatheter aortic valve replacement
transthyretin
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
received:
01
08
2019
revised:
13
09
2019
accepted:
16
09
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
19
5
2020
Statut:
ppublish
Résumé
The prevalence of calcific aortic stenosis (AS) and of cardiac amyloidosis (CA) increases with age, and their association is not uncommon in the elderly. The identification of CA is particularly challenging in patients with AS because these 2 conditions share several features. It is estimated that ≤15% of the AS population and ≤30% of the subset with low-flow, low-gradient pattern may have CA. In patients with AS, CA is associated with increased risk of heart failure, mortality, and treatment futility with aortic valve replacement. In case of suspicion of CA, it is thus crucial to confirm the diagnosis to guide therapeutic management of AS and eventually implement recently developed pharmacological treatment dedicated to transthyretin amyloidosis. Given the high surgical risk of patients with AS and concomitant CA, transcatheter aortic valve replacement may be preferred to surgery in these patients.
Identifiants
pubmed: 31753206
pii: S0735-1097(19)37926-4
doi: 10.1016/j.jacc.2019.09.056
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2638-2651Informations de copyright
Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.