Genetic Predisposition to Drug-Induced Liver Injury.

Chemical and Drug Induced Liver Injury / epidemiology Genetic Predisposition to Disease Genome-Wide Association Study HLA Antigens / genetics Humans Pharmacogenomic Testing / methods Pharmacogenomic Variants Predictive Value of Tests
Candidate gene studies Drug metabolism Genome-wide association studies Human leukocyte antigen Pharmacogenetics Pharmacogenomics

Journal

Clinics in liver disease
ISSN: 1557-8224
Titre abrégé: Clin Liver Dis
Pays: United States
ID NLM: 9710002

Informations de publication

Date de publication:
02 2020
Historique:
entrez: 23 11 2019
pubmed: 23 11 2019
medline: 27 7 2021
Statut: ppublish

Résumé

Identification of genetic predisposition to drug-induced liver injury (DILI) is of paramount importance. Early candidate gene studies have identified various polymorphisms in drug-metabolizing genes that infer increased DILI susceptibility. Few of these have been confirmed in more recent genome-wide association studies, which have identified several specific human leukocyte antigen (HLA) alleles. The low incidence rate of DILI, however, leads to a low positive predictive value for currently identified genetic variations, making them unsuitable for pre-prescription screening. HLA screening incorporated into clinical practice can aid the diagnostic process resulting in enhanced diagnostic accuracy and confidence.

Identifiants

DOI: 10.1016/j.cld.2019.08.003 PMID: 31753244
pubmed: 31753244
pii: S1089-3261(19)30053-4
doi: 10.1016/j.cld.2019.08.003
pii:
doi:

Substances chimiques

HLA Antigens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-23

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Camilla Stephens (C)

Unidad de Gestión Clínica de Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Boulevard Louis Pasteur 32, Málaga, 29071 Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.

Raúl J Andrade (RJ)

Unidad de Gestión Clínica de Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Boulevard Louis Pasteur 32, Málaga, 29071 Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain. Electronic address: andrade@uma.es.

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Classifications MeSH

questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Test pharmacogénomique › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variants pharmacogénomiques › Genetic Predisposition to Drug-Induced Liver Injury.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Genetic Predisposition to Drug-Induced Liver Injury.