To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.
Administration, Oral
Adrenergic beta-Antagonists
/ administration & dosage
Eyelid Neoplasms
/ drug therapy
Female
Hemangioma, Capillary
/ drug therapy
Humans
Infant
Injections, Intralesional
Male
Orbital Neoplasms
/ drug therapy
Pilot Projects
Propranolol
/ administration & dosage
Prospective Studies
Treatment Outcome
Capillary hemangioma
intralesional propranolol
oral propranolol
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
11
7
2020
Statut:
ppublish
Résumé
A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas. Twenty patients were prospectively randomized to two groups of ten each. Group 1 was initiated on oral propranolol 1 mg/kg/day titrated to final dose of 3 mg/kg/day over 1 week which was continued for 6 months and then tapered over 1 week; Group 2 received 3 doses of direct intralesional propranolol hydrochloride 1 mg/ml; 0.2 ml/cm 4-6 weeks apart. Hemangioma area and corneal astigmatism were measured. Within each group at 6 months there was a significant reduction in area (group 1: 83.48 ± 11.67%,P= 0.0019; group 2: 67.78 ± 21.71%,P= 0.0019) and improvement in astigmatism (pre, post: group 1: 2.98D @ 179.8°, 1.13D @ 179.8°,P= 0.0045; group 2: 1.62D @ 90.16°, 0.75D @ 179.9°,P= 0.0001). There was no difference in area reduction (P = 0.056), change in appearance (P = 0.085), ptosis (P = 0.23) and side effects (lethargy, poor feeding;P= 0.171) between the two groups. Efficacy and side effects with intralesional propranolol are comparable to oral propranolol for periorbital and eyelid lesions.
Identifiants
pubmed: 31755431
pii: IndianJOphthalmol_2019_67_12_1974_271389
doi: 10.4103/ijo.IJO_59_19
pmc: PMC6896529
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Propranolol
9Y8NXQ24VQ
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1974-1980Commentaires et corrections
Type : CommentIn
Déclaration de conflit d'intérêts
None
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