Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
Animals
Anticonvulsants
/ pharmacology
Anxiety
/ drug therapy
CA1 Region, Hippocampal
/ drug effects
Calcium Channel Blockers
/ pharmacology
Calcium Channels
/ drug effects
Convulsants
/ toxicity
Disease Progression
Electric Stimulation
Electroshock
/ adverse effects
Epilepsy, Complex Partial
/ drug therapy
Excitatory Postsynaptic Potentials
/ drug effects
Exploratory Behavior
/ drug effects
Ion Transport
/ drug effects
Kindling, Neurologic
/ drug effects
Long-Term Potentiation
/ drug effects
Male
Mice
Mice, Inbred C57BL
Neural Pathways
/ drug effects
Pentylenetetrazole
/ toxicity
Pyrazines
/ pharmacology
Recognition, Psychology
/ drug effects
Seizures
/ drug therapy
Sodium Channels
/ drug effects
Tetramethylpyrazine
antiepileptic drugs
calcium channels
epileptogenesis
limbic epilepsy
long-term potentiation
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
18 12 2019
18 12 2019
Historique:
pubmed:
23
11
2019
medline:
22
9
2020
entrez:
23
11
2019
Statut:
ppublish
Résumé
Antiepileptic drugs (AEDs) are the primary agents prescribed for clinical management of limbic epilepsy. However, high incidence of pharmacoresistance and a limited armory of drugs for inhibiting the pathological progression of epilepsy pose major obstacles to managing epilepsy. Here, we investigated the effect of tetramethylpyrazine (TMP), the main bioactive alkaloid isolated from the oriental medicine
Identifiants
pubmed: 31756074
doi: 10.1021/acschemneuro.9b00575
doi:
Substances chimiques
Anticonvulsants
0
Calcium Channel Blockers
0
Calcium Channels
0
Convulsants
0
Pyrazines
0
Sodium Channels
0
tetramethylpyrazine
V80F4IA5XG
Pentylenetetrazole
WM5Z385K7T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM