La chirurgie peut être envisagée si les médicaments ne contrôlent pas les crises.
Chirurgie neurologiqueContrôle des crises
#3
Les thérapies alternatives sont-elles efficaces ?
Certaines thérapies alternatives, comme la méditation, peuvent aider à gérer le stress.
Thérapies alternativesGestion du stress
#4
Comment les médicaments agissent-ils sur l'embrasement ?
Ils stabilisent l'activité électrique du cerveau, réduisant ainsi la fréquence des crises.
Stabilisation électriqueFréquence des crises
#5
Y a-t-il des effets secondaires aux traitements ?
Oui, les médicaments peuvent avoir des effets secondaires comme la somnolence ou des vertiges.
Effets secondairesSomnolence
Complications
5
#1
Quelles complications peuvent survenir ?
Les complications incluent des blessures lors des crises et des troubles cognitifs persistants.
ComplicationsTroubles cognitifs
#2
L'embrasement peut-il entraîner des troubles mentaux ?
Oui, il peut augmenter le risque de troubles mentaux comme la dépression et l'anxiété.
Troubles mentauxDépression
#3
Y a-t-il un risque accru de mortalité ?
Oui, le syndrome de mort subite en épilepsie est une complication rare mais grave.
Mort subiteSyndrome de mort subite en épilepsie
#4
Les complications sont-elles réversibles ?
Certaines complications peuvent être réversibles avec un traitement approprié.
RéversibilitéTraitement approprié
#5
Comment gérer les complications ?
La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier.
Gestion des complicationsApproche multidisciplinaire
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque ?
Les antécédents familiaux, les traumatismes crâniens et l'alcoolisme sont des facteurs de risque.
Antécédents familiauxTraumatismes crâniens
#2
Le stress influence-t-il l'embrasement ?
Oui, le stress peut déclencher des crises et aggraver l'embrasement neurologique.
StressDéclencheurs
#3
L'âge joue-t-il un rôle dans l'embrasement ?
Oui, l'âge peut influencer la susceptibilité aux crises et à l'embrasement.
ÂgeSusceptibilité
#4
Les infections cérébrales sont-elles un risque ?
Oui, certaines infections peuvent augmenter le risque d'embrasement neurologique.
Infections cérébralesRisque
#5
L'usage de drogues affecte-t-il l'embrasement ?
Oui, l'usage de drogues peut déclencher des crises et exacerber l'embrasement.
DroguesExacerbation
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Programa de Pós-Graduação em Ciências Biológicas - Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Ciências Biológicas - Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: adriana.simon@ufrgs.br.
Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Departments of Medicine, and Neurology & Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada.
Integrated Program in Neuroscience, McGill University, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada.
Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Departments of Medicine, and Neurology & Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada. jesper.sjostrom@mcgill.ca.
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: jatinderkatyal.aiims@gmail.com.
Laboratory of Rheumatology & Institute of TCM Clinical Basic Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, No.548 Binwen Road, Hangzhou, Zhejiang, 310053, China. xuzhenghao@zcmu.edu.cn.
Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. xuzhenghao@zcmu.edu.cn.
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. xuzhenghao@zcmu.edu.cn.
Neuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia.
This study aimed to assess the usefulness of the parent version of the KINDL...
The ExAMIN Youth SA study was designed to investigate lifestyle behaviours, including psychosocial factors that may adversely impact on cardiovascular health of children. Construct validity was examin...
The study included children (n = 1088) aged between 5 and 10 years in North-West, South Africa. The reliability coefficients of the original factors could not be reproduced in this data set, with the ...
We confirmed a new factor structure of the parent version of the KINDL...
Epilepsy is characterized by a sustained depolarization and repeated discharge of neurons, attributed to overstimulation of N-methyl-D-aspartate receptors (NMDAr). Herein, we propose that probenecid (...
Although numerous studies have acknowledged disparities in epilepsy-related disease processes between young and aged animals, little is known about how epilepsy changes from young adulthood to middle ...
The impact of dopamine on synaptic plasticity and cognitive function following seizure is not well understood. Here, using optogenetics in the freely-behaving animal, we examined exploratory behavior ...
One of the mechanisms of epileptgenesis is impairment of inhibitory neural circuits. Several studies have compared neural changes among subtypes of gamma-aminobutyric acid-related (GABAergic) neurons ...
Male rats were injected with pentylenetetrazole (PTZ kindling: n = 30) or saline (control: n = 15) every other day to observe the development of epileptic seizure stages. Two time points were identifi...
Bimodal changes in seizure stages were observed in response to PTZ kindling. The increase of seizure stage was transiently suppressed after 8 or 10 injections, and then progressed again by the 16th in...
PTZ kindling induces bimodal changes in the epileptic seizure stage. Seizure stage is transiently suppressed after short-term PTZ injection with GAD65 upregulation in SOM...
Previous research have reported that modulating the gut microbiome composition by fecal microbiota transplantation and probiotic administration can alleviate seizure occurrence and severity. Saccharom...
Temporal lobe epilepsy (TLE) development is associated with dysregulation of glutamatergic transmission in the hippocampus; however, detailed molecular mechanisms of pathological changes are still poo...
The repressor element-1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is an epigenetic master regulator that plays a crucial role during nervous system development and ...
Progressive spreading of α-synuclein via gut-brain axis has been hypothesized in the pathogenesis of Parkinson's disease (PD). However, the source of seeding-capable α-synuclein in the gastrointestina...
We aimed to investigate whether blood-derived α-synuclein might contribute to PD pathology via a gut-driven pathway and involve GIT microbiota....
The GIT expression of α-synuclein and the transmission of extracellular vesicles (EVs) derived from erythrocytes/red blood cells (RBCs), with their cargo α-synuclein, to the GIT were explored with var...
This study demonstrated that RBC-EVs can effectively transport α-synuclein to the GIT in a region-dependent manner, along with variations closely associated with regional differences in the expression...
By demonstrating the transportation of α-synuclein through RBC-EVs to the GIT, and its potential association with gut-vascular barrier markers and gut microbiome, this work highlights a potential mech...
Excessive anxiety is a mental disorder, and its treatment involves the use of benzodiazepines, a class of drugs that enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the G...
Adult male rats were injected with PTZ 20 times every other day, and stages of seizure onset were classified according to the Racine staging system. Anxiety-like behaviors were measured after 10 and 2...
Bimodal changes in seizure stage were observed in response to PTZ kindling. The increase in the seizure stage was transiently suppressed after 10 injections, and this decrease in epileptic sensitivity...
PTZ kindling induced bimodal changes in the seizure stage. Anxiety-like behaviors decreased with transient decrease in epileptic sensitivity and returned to control levels with the disappearance of th...