PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.
Cognitive impairment
Depression
Epileptogenesis
Kindling
Pentylenetetrazole
Refractory epilepsy
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
12
01
2021
accepted:
14
08
2021
pubmed:
25
8
2021
medline:
1
4
2022
entrez:
24
8
2021
Statut:
ppublish
Résumé
Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is also a simple and well accepted model of chronic epilepsy. PTZ kindling has been explored for studying epileptogenesis, epilepsy-associated comorbidities, and refractory epilepsy. This review summarizes the potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy.
Identifiants
pubmed: 34427842
doi: 10.1007/s11011-021-00823-3
pii: 10.1007/s11011-021-00823-3
doi:
Substances chimiques
Anticonvulsants
0
Pentylenetetrazole
WM5Z385K7T
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1573-1590Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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