Intravenous Acetaminophen (Paracetamol) for Postcraniotomy Pain: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Acetaminophen / therapeutic use Administration, Intravenous / methods Analgesics, Non-Narcotic / therapeutic use Humans Pain, Postoperative / drug therapy Randomized Controlled Trials as Topic Treatment Outcome
Acetaminophen Craniotomy Meta-analysis Postoperative pain

Journal

World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 10 10 2019
accepted: 12 11 2019
pubmed: 23 11 2019
medline: 7 3 2020
entrez: 23 11 2019
Statut: ppublish

Résumé

Acute pain control after supratentorial craniotomy is considered among the most important indicators of postoperative recovery. The aim of this study was to determine the effects of intravenous acetaminophen on postcraniotomy pain. We searched databases including Embase, Scopus, Medline, Cochrane Library, and Web of Science until April 2019. Cochran Q test and I Out of 479 reports, 5 randomized controlled trials met the inclusion criteria and were appropriate for our meta-analysis, which included a total of 2635 patients. The pooled results of included clinical trials indicated that paracetamol intake significantly decreased rescue dose (SMD, -0.67; 95% CI, -1.15 to -0.19; P < 0.01; I The results of this systematic review and meta-analysis indicate that preoperative intravenous administration of acetaminophen is associated with decreased postoperative pain, need for rescue analgesics, and dosages of analgesics after craniotomy surgery.

Sections du résumé

BACKGROUND BACKGROUND
Acute pain control after supratentorial craniotomy is considered among the most important indicators of postoperative recovery. The aim of this study was to determine the effects of intravenous acetaminophen on postcraniotomy pain.
METHODS METHODS
We searched databases including Embase, Scopus, Medline, Cochrane Library, and Web of Science until April 2019. Cochran Q test and I
RESULTS RESULTS
Out of 479 reports, 5 randomized controlled trials met the inclusion criteria and were appropriate for our meta-analysis, which included a total of 2635 patients. The pooled results of included clinical trials indicated that paracetamol intake significantly decreased rescue dose (SMD, -0.67; 95% CI, -1.15 to -0.19; P < 0.01; I
CONCLUSIONS CONCLUSIONS
The results of this systematic review and meta-analysis indicate that preoperative intravenous administration of acetaminophen is associated with decreased postoperative pain, need for rescue analgesics, and dosages of analgesics after craniotomy surgery.

Identifiants

DOI: 10.1016/j.wneu.2019.11.066 PMID: 31756498
pubmed: 31756498
pii: S1878-8750(19)32904-3
doi: 10.1016/j.wneu.2019.11.066
pii:
doi:

Substances chimiques

Analgesics, Non-Narcotic 0
Acetaminophen 362O9ITL9D

Types de publication

Journal Article Meta-Analysis Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

569-576

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Fariborz Ghaffarpasand (F)

Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.

Ehsan Dadgostar (E)

Halal Research Center of IRI, Food and Drug Administration, Tehran, Iran.

Ghazal Ilami (G)

Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.

Fatemeh Shoaee (F)

Department of Obstetrics and Gynecology, Shiraz Kowsar Hospital, Shiraz, Iran.

Amin Niakan (A)

Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: aminniakan@yahoo.com.

Sara Aghabaklou (S)

Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA.

Maryam Ghadimi (M)

Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.

Sogand Goudarzi (S)

Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical School, Harvard University, Boston, Massachusetts, USA.

Maryam Dehghankhalili (M)

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Mohammad Hesam Alavi (MH)

Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Acétaminophène › Intravenous Acetaminophen (Paracetamol) for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie intraveineuse › Intravenous Acetaminophen (Paracetamol) for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Analgésiques non narcotiques › Intravenous Acetaminophen (Paracetamol) for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intravenous Acetaminophen (Paracetamol) for...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur postopératoire › Intravenous Acetaminophen (Paracetamol) for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Intravenous Acetaminophen (Paracetamol) for...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Intravenous Acetaminophen (Paracetamol) for...