Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation.

Animals Glucagon-Like Peptide-1 Receptor / agonists Hypoglycemic Agents / pharmacology Liraglutide / pharmacology Lymphocyte Activation / drug effects Male Mice Mice, Inbred C57BL Mice, Knockout Nephritis / immunology T-Lymphocytes / drug effects

Journal

The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502

Informations de publication

Date de publication:
02 2020
Historique:
received: 07 11 2018
revised: 20 09 2019
accepted: 01 10 2019
pubmed: 25 11 2019
medline: 6 5 2020
entrez: 25 11 2019
Statut: ppublish

Résumé

Glucagon-like peptide (GLP)-1 analogs such as liraglutide improved albuminuria in patients with type 2 diabetes in large randomized controlled trials. One of the suspected mechanisms is the anti-inflammatory potential of GLP-1 receptor (Glp1r) agonism. Thus, the anti-inflammatory action of Glp1r agonism was tested in a nondiabetic, T-cell-mediated murine model of nephrotoxic serum nephritis (NTS). The role of Glp1r in NTS was evaluated by using Glp1r

Identifiants

DOI: 10.1016/j.ajpath.2019.10.008 PMID: 31759969
pubmed: 31759969
pii: S0002-9440(19)30806-5
doi: 10.1016/j.ajpath.2019.10.008
pii:
doi:

Substances chimiques

Glp1r protein, mouse 0
Glucagon-Like Peptide-1 Receptor 0
Hypoglycemic Agents 0
Liraglutide 839I73S42A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

400-411

Informations de copyright

Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Auteurs

Foteini Moschovaki Filippidou (F)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Alexander H Kirsch (AH)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Matthias Thelen (M)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Máté Kétszeri (M)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Katharina Artinger (K)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Ida Aringer (I)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Corinna Schabhüttl (C)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Agnes A Mooslechner (AA)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Bianca Frauscher (B)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Marion Pollheimer (M)

Institute of Pathology, Medical University of Graz, Graz, Austria.

Tobias Niedrist (T)

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Andreas Meinitzer (A)

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Daniel J Drucker (DJ)

Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Thomas R Pieber (TR)

Clinical Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Philipp Eller (P)

Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Alexander R Rosenkranz (AR)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Akos Heinemann (A)

Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria; BioTechMed, Graz, Austria.

Kathrin Eller (K)

Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address: kathrin.eller@medunigraz.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone gastrointestinale › Récepteurs des peptides similaires au glucagon › Récepteur du peptide-1 similaire au glucagon › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Liraglutide › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Glucagon-Like Peptide-1 Receptor Agonism...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Glucagon-Like Peptide-1 Receptor Agonism...