Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS.
CNS myelination
Caspr
Neurofascin
in vivo imaging
mouse
oligodendrocyte
zebrafish
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
16 12 2019
16 12 2019
Historique:
received:
27
06
2019
revised:
10
09
2019
accepted:
17
10
2019
pubmed:
26
11
2019
medline:
11
6
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
Selection of the correct targets for myelination and regulation of myelin sheath growth are essential for central nervous system (CNS) formation and function. Through a genetic screen in zebrafish and complementary analyses in mice, we find that loss of oligodendrocyte Neurofascin leads to mistargeting of myelin to cell bodies, without affecting targeting to axons. In addition, loss of Neurofascin reduces CNS myelination by impairing myelin sheath growth. Time-lapse imaging reveals that the distinct myelinating processes of individual oligodendrocytes can engage in target selection and sheath growth at the same time and that Neurofascin concomitantly regulates targeting and growth. Disruption to Caspr, the neuronal binding partner of oligodendrocyte Neurofascin, also impairs myelin sheath growth, likely reflecting its association in an adhesion complex at the axon-glial interface with Neurofascin. Caspr does not, however, affect myelin targeting, further indicating that Neurofascin independently regulates distinct aspects of CNS myelination by individual oligodendrocytes in vivo.
Identifiants
pubmed: 31761670
pii: S1534-5807(19)30863-9
doi: 10.1016/j.devcel.2019.10.016
pmc: PMC6912162
pii:
doi:
Substances chimiques
Nerve Growth Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
730-744.e6Subventions
Organisme : Wellcome Trust
ID : 214244/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P006272/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107008
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207483/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095722/Z/11/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102836/Z/13/Z
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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