Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents.
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
Biological Transport
Breast Neoplasms
/ drug therapy
Cell Proliferation
Cisplatin
/ pharmacology
DNA
/ metabolism
Drug Resistance, Neoplasm
/ drug effects
Female
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Lung Neoplasms
/ drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Oxaliplatin
/ pharmacology
Oxidoreductases Acting on CH-NH Group Donors
/ metabolism
Polyamines
/ metabolism
Prodrugs
/ chemistry
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Polyamine Oxidase
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
26 12 2019
26 12 2019
Historique:
pubmed:
26
11
2019
medline:
23
6
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
Diverse platinum drug candidates have been designed to improve inhibitory potency and overcome resistance for orthotopic tumors. However, the antimetastatic properties have rarely been reported. We herein report that homospermidineplatin (
Identifiants
pubmed: 31765154
doi: 10.1021/acs.jmedchem.9b01641
doi:
Substances chimiques
Antineoplastic Agents
0
Polyamines
0
Prodrugs
0
Oxaliplatin
04ZR38536J
DNA
9007-49-2
Oxidoreductases Acting on CH-NH Group Donors
EC 1.5.-
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM