Assessing the feasibility of hyperpolarized
cystic fibrosis
fractional ventilation
hyperpolarized 129Xe
lung clearance index
multiple-breath washout
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
15
08
2019
revised:
11
10
2019
accepted:
05
11
2019
pubmed:
26
11
2019
medline:
15
5
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
To assess the feasibility of hyperpolarized A total of 17 pediatric participants were recruited (mean age 11.7 ± 2.8 years), including 7 children with clinically stable CF and 10 aged-matched healthy controls. Pulmonary function tests were performed, including spirometry, to measure the forced expiratory volume in 1 second and nitrogen multiple-breath washout to measure the lung clearance index. Hyperpolarized The forced expiratory volume in 1 second was similar in both groups (P = .32), but there was a statistically significant difference in lung clearance index between healthy and CF participants (P = .001). With variable T This study demonstrates that hyperpolarized
Substances chimiques
Xenon Isotopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
304-311Subventions
Organisme : CIHR
ID : MOP 123431
Pays : Canada
Organisme : CIHR
ID : PJT 153099
Pays : Canada
Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
Références
O'Sullivan BP, Freedman SD. Cystic fibrosis. Lancet. 2009;373:1891-1904.
Gustafsson PM, Aurora P, Lindblad A. Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J. 2003;22:972-979.
Konstan MW, Morgan WJ, Butler SM, et al. Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis. J Pediatr. 2007;151:134-139.
Aurora P, Bush A, Gustafsson P, et al. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med. 2005;171:249-256.
Walkup LL, Thomen RP, Akinyi TG, et al. Feasibility, tolerability and safety of pediatric hyperpolarized 129Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis. Pediatr Radiol. 2016;46:1651-1662.
Santyr G, Kanhere N, Morgado F, Rayment JH, Ratjen F, Couch MJ. Hyperpolarized gas magnetic resonance imaging of pediatric cystic fibrosis lung disease. Acad Radiol. 2019;26:344-354.
Thomen RP, Walkup LL, Roach DJ, Cleveland ZI, Clancy JP, Woods JC. Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients. J Cyst Fibros. 2017;16:275-282.
O’Sullivan B, Couch M, Roche JP, et al. Assessment of repeatability of hyperpolarized gas MR ventilation functional imaging in cystic fibrosis. Acad Radiol. 2014;21:1524-1529.
Smith L, Marshall H, Aldag I, et al. Longitudinal assessment of children with mild cystic fibrosis using hyperpolarized gas lung magnetic resonance imaging and lung clearance index. Am J Respir Crit Care Med. 2018;197:397-400.
Rayment JH, Couch MJ, McDonald N, et al. Hyperpolarised (129)Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis. Eur Respir J. 2019;53:1802188.
Kanhere N, Couch MJ, Kowalik K, et al. Correlation of lung clearance index with hyperpolarized 129Xe magnetic resonance imaging in pediatric subjects with cystic fibrosis. Am J Respir Crit Care Med. 2017;196:1073-1075.
Walkup LL, Thomen RP, Bell E, et al. Quantification of regional ventilation heterogeneity of early cystic fibrosis lung disease via 129Xe magnetic resonance imaging: comparison with PFT and LCI. Pediatr Pulmonol. 2016;51:351.
Marshall H, Horsley A, Taylor CJ, et al. Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI. Thorax. 2017;72:760-762.
Horn FC, Deppe MH, Marshall H, Parra-Robles J, Wild JM. Quantification of regional fractional ventilation in human subjects by measurement of hyperpolarized 3He washout with 2D and 3D MRI. J Appl Physiol. 2014;116:129-139.
Horn FC, Rao M, Stewart NJ, Wild JM. Multiple breath washout of hyperpolarized 129Xe and 3He in human lungs with three-dimensional balanced steady-state free-precession imaging. Magn Reson Med. 2017;77:2288-2295.
Couch MJ, Ouriadov A, Santyr GE. Regional ventilation mapping of the rat lung using hyperpolarized 129Xe magnetic resonance imaging. Magn Reson Med. 2012;68:1623-1631.
Hamedani H, Clapp JT, Kadlecek SJ, et al. Regional fractional ventilation by using multibreath wash-in (3)He MR imaging. Radiology. 2016;279:917-924.
Horn FC, Marshall H, Siddiqui S, et al. Ventilation heterogeneity in obstructive airways disease-comparing multi-breath washout-imaging with global lung measurements. In: Proceedings of the 23rd Annual Meeting of ISMRM, Toronto, Canada, 2015. p 852.
Morgado F, Couch MJ, Stirrat E, Santyr G. Effect of T1 relaxation on ventilation mapping using hyperpolarized 129Xe multiple breath wash-out imaging. Magn Reson Med. 2018;80:2670-2680.
Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26:319-338.
Robinson PD, Latzin P, Verbanck S, et al. Consensus statement for inert gas washout measurement using multiple- and single- breath tests. Eur Respir J. 2013;41:507-522.
Jensen R, Stanojevic S, Gibney K, et al. Multiple breath nitrogen washout: a feasible alternative to mass spectrometry. PLoS ONE. 2013;8:e56868.
Driehuys B, Martinez-Jimenez S, Cleveland ZI, et al. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology. 2012;262:279-289.
Hughes PJC, Smith L, Chan H-F, et al. Assessment of the influence of lung inflation state on the quantitative parameters derived from hyperpolarized gas lung ventilation MRI in healthy volunteers. J Appl Physiol (1985). 2019;126:183-192.
Gustafsson PM, Robinson PD, Gilljam M, Lindblad A, Houltz BK. Slow and fast lung compartments in cystic fibrosis measured by nitrogen multiple-breath washout. J Appl Physiol (1985). 2014;117:720-729.
Whitfield CA, Horsley A, Jensen OE, et al. Inferring the distribution of ventilation in the lung from multiple breath washout: a validation study in cystic fibrosis. J Cyst Fibros. 2019;18:S13.
Smith LJ, Collier GJ, Marshall H, et al. Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout. Eur Respir J. 2018;52:1800821.
Doganay O, Matin TN, McIntyre A, et al. Fast dynamic ventilation MRI of hyperpolarized (129) Xe using spiral imaging. Magn Reson Med. 2018;79:2597-2606.
Zanette B, Santyr G. Accelerated interleaved spiral-IDEAL imaging of hyperpolarized (129) Xe for parametric gas exchange mapping in humans. Magn Reson Med. 2019;82:1113-1119.
He M, Driehuys B, Que LG, Huang YT. Using hyperpolarized 129Xe MRI to quantify the pulmonary ventilation distribution. Acad Radiol. 2016;23:1521-1531.
Ouriadov AV, Fox MS, Couch MJ, Li T, Ball IK, Albert MS. In vivo regional ventilation mapping using fluorinated gas MRI with an x-centric FGRE method. Magn Reson Med. 2015;74:550-557.
Couch MJ, Fox MS, Viel C, et al. Fractional ventilation mapping using inert fluorinated gas MRI in rat models of inflammation and fibrosis. NMR Biomed. 2016;29:545-552.
Gutberlet M, Kaireit TF, Voskrebenzev A, et al. Free-breathing dynamic (19)F gas MR imaging for mapping of regional lung ventilation in patients with COPD. Radiology. 2018;286:1040-1051.
Bauman G, Puderbach M, Deimling M, et al. Non-contrast-enhanced perfusion and ventilation assessment of the human lung by means of fourier decomposition in proton MRI. Magn Reson Med. 2009;62:656-664.
Veldhoen S, Weng AM, Knapp J, et al. Self-gated non-contrast-enhanced functional lung MR imaging for quantitative ventilation assessment in patients with cystic fibrosis. Radiology. 2017;283:242-251.
Kaireit TF, Gutberlet M, Voskrebenzev A, et al. Comparison of quantitative regional ventilation-weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients. J Magn Reson Imaging. 2018;47:1534-1541.