Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation.

Animals Cleft Palate / embryology Craniofacial Abnormalities / embryology Female Gene Expression Regulation, Developmental / genetics Genes, Homeobox Homeodomain Proteins / genetics Male Mice Mice, Inbred C57BL Morphogenesis Nerve Tissue Proteins / metabolism Osteogenesis PAX9 Transcription Factor / genetics Paired Box Transcription Factors Palate / metabolism Signal Transduction / genetics Transcription Factors / genetics

Journal

Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762

Informations de publication

Date de publication:
15 02 2020
Historique:
received: 16 08 2019
revised: 30 10 2019
accepted: 15 11 2019
pubmed: 26 11 2019
medline: 2 9 2020
entrez: 26 11 2019
Statut: ppublish

Résumé

In this study, we investigated the role of the transcription factor Six2 in palate development. Six2 was selected using the SysFACE tool to predict genes from the 2p21 locus, a region associated with clefting in humans by GWAS, that are likely to be involved in palatogenesis. We functionally validated the predicted role of Six2 in palatogenesis by showing that 22% of Six2 null embryos develop cleft palate. Six2 contributes to palatogenesis by promoting mesenchymal cell proliferation and regulating bone formation. The clefting phenotype in Six2

Identifiants

DOI: 10.1016/j.ydbio.2019.11.010 PMID: 31765609 PMC: PMC7568837
pubmed: 31765609
pii: S0012-1606(19)30492-0
doi: 10.1016/j.ydbio.2019.11.010
pmc: PMC7568837
mid: NIHMS1545915
pii:
doi:

Substances chimiques

Homeodomain Proteins 0
Nerve Tissue Proteins 0
PAX9 Transcription Factor 0
Paired Box Transcription Factors 0
Pax9 protein, mouse 0
Six2 protein, mouse 0
Transcription Factors 0
PAX1 transcription factor 142661-96-9

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

246-256

Subventions

Organisme : NIDCR NIH HHS
ID : T90 DE023520
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE013941
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026433
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE024776
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026172
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have no conflicts of interest to report.

Références

Nat Commun. 2017 Mar 13;8:14759
pubmed: 28287101
J Pediatr. 2009 Dec;155(6):909-13
pubmed: 19656524
Nat Genet. 2010 Jan;42(1):24-6
pubmed: 20023658
Front Physiol. 2017 Nov 23;8:955
pubmed: 29218017
J Dent Res. 2019 May;98(5):572-579
pubmed: 30905259
Hum Mol Genet. 2005 Dec 1;14(23):3605-17
pubmed: 16236760
Nat Genet. 2008 Nov;40(11):1341-7
pubmed: 18836445
PLoS Genet. 2015 Mar 23;11(3):e1005059
pubmed: 25798845
J Craniofac Surg. 2011 Sep;22(5):1722-6
pubmed: 21959420
J Anat. 2010 Jan;216(1):80-91
pubmed: 19900183
Nat Commun. 2015 Mar 16;6:6414
pubmed: 25775280
Development. 2013 Dec;140(23):4709-18
pubmed: 24173808
BMC Pediatr. 2015 Feb 14;15:8
pubmed: 25884320
Am J Hum Genet. 2015 Mar 5;96(3):397-411
pubmed: 25704602
Am J Med Genet A. 2016 Feb;170A(2):487-491
pubmed: 26581443
Am J Hum Genet. 2018 Jun 7;102(6):1143-1157
pubmed: 29805042
EMBO J. 2006 Nov 1;25(21):5214-28
pubmed: 17036046
Am J Hum Genet. 2016 Apr 7;98(4):744-54
pubmed: 27018472
Hum Mol Genet. 2015 Apr 15;24(8):2330-48
pubmed: 25556186
Nat Commun. 2017 Feb 24;8:14364
pubmed: 28232668
Development. 1999 Jan;126(2):359-69
pubmed: 9847249
Hum Genet. 2018 Dec;137(11-12):941-954
pubmed: 30417254
Development. 2001 Oct;128(20):3975-86
pubmed: 11641221
Development. 2016 Feb 15;143(4):595-608
pubmed: 26884396
Nucleic Acids Res. 2018 Jan 4;46(D1):D875-D885
pubmed: 29036527
Am J Med Genet A. 2007 Jun 1;143A(11):1143-9
pubmed: 17497721
Development. 2017 Oct 15;144(20):3819-3828
pubmed: 28893947
Nat Genet. 2012 Sep;44(9):968-71
pubmed: 22863734
Mech Dev. 2004 Oct;121(10):1211-22
pubmed: 15327782
Nat Genet. 2009 Apr;41(4):473-7
pubmed: 19270707
BMC Bioinformatics. 2010 Nov 08;11:548
pubmed: 21059217
FEBS Lett. 1996 Sep 16;393(2-3):259-63
pubmed: 8814301
Cleft Palate Craniofac J. 2017 Jan;54(1):90-93
pubmed: 26882109
J Anat. 2005 Nov;207(5):655-67
pubmed: 16313398
Development. 2012 Jan;139(2):231-43
pubmed: 22186724
Hum Mol Genet. 2019 Mar 15;28(6):1038-1051
pubmed: 30452639
J Hum Genet. 2006;51(1):38-46
pubmed: 16247549
Hum Mol Genet. 2015 Nov 1;24(21):6174-85
pubmed: 26307084
Nat Genet. 2010 Jun;42(6):525-9
pubmed: 20436469
Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1617-27
pubmed: 22323457
Nat Methods. 2010 Apr;7(4):248-9
pubmed: 20354512
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9360-5
pubmed: 12878728
Cleft Palate Craniofac J. 2004 Jul;41(4):381-6
pubmed: 15222794
Dev Cell. 2012 Sep 11;23(3):637-51
pubmed: 22902740
Dev Biol. 2010 Aug 15;344(2):720-30
pubmed: 20515681
Development. 2016 Nov 15;143(22):4115-4126
pubmed: 27660324
Dev Biol. 2011 Feb 15;350(2):520-31
pubmed: 21185278
Nat Rev Genet. 2011 Mar;12(3):167-78
pubmed: 21331089
Nat Protoc. 2009;4(7):1073-81
pubmed: 19561590
Genes Dev. 1998 Sep 1;12(17):2735-47
pubmed: 9732271

Auteurs

Yan Yan Sweat (YY)

Department of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, 52242, USA.

Mason Sweat (M)

Department of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, 52242, USA.

Maurisa Mansaray (M)

Department of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, 52242, USA.

Huojun Cao (H)

Department of Endodontics, College of Dentistry, The University of Iowa, Iowa City, IA, 52242, USA; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, 52242, USA.

Steven Eliason (S)

Department of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, 52242, USA.

Waisu L Adeyemo (WL)

Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria.

Lord J J Gowans (LJJ)

Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Mekonen A Eshete (MA)

Addis Ababa University, School of Public Health, Addis Ababa, Ethiopia.

Deepti Anand (D)

Department of Biological Sciences, University of Delaware, Newark, DE, 19716, USA.

Camille Chalkley (C)

Department of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, 52242, USA.

Irfan Saadi (I)

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.

Salil A Lachke (SA)

Department of Biological Sciences, University of Delaware, Newark, DE, 19716, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, 19716, USA.

Azeez Butali (A)

Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, 52242, USA; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, 52242, USA.

Brad A Amendt (BA)

Department of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, 52242, USA; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, 52242, USA. Electronic address: brad-amendt@uowa.edu.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système stomatognathique › Malformations de la bouche › Fente palatine › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations de l'appareil locomoteur › Malformations crâniofaciales › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes du développement › Gènes homéotiques › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription PAX › Facteur de transcription PAX9 › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription PAX › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Système stomatognathique › Bouche › Palais › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Six2 regulates Pax9 expression, palatogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Six2 regulates Pax9 expression, palatogenesis...