Role of ACTN4 in Tumorigenesis, Metastasis, and EMT.
ACTN4
cancer cell proliferation
cell motility
epithelial-mesenchymal transition
metastasis
tumorigenesis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 11 2019
13 11 2019
Historique:
received:
11
09
2019
revised:
08
11
2019
accepted:
10
11
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
8
7
2020
Statut:
epublish
Résumé
The actin-binding protein ACTN4 belongs to a family of actin-binding proteins and is a non-muscle alpha-actinin that has long been associated with cancer development. Numerous clinical studies showed that changes in ACTN4 gene expression are correlated with aggressiveness, invasion, and metastasis in certain tumors. Amplification of the 19q chromosomal region where the gene is located has also been reported. Experimental manipulations with ACTN4 expression further confirmed its involvement in cell proliferation, motility, and epithelial-mesenchymal transition (EMT). However, both clinical and experimental data suggest that the effects of ACTN4 up- or down-regulation may vary a lot between different types of tumors. Functional studies demonstrated its engagement in a number of cytoplasmic and nuclear processes, ranging from cytoskeleton reorganization to regulation of different signaling pathways. Such a variety of functions may be the reason behind cell type and cell line specific responses. Herein, we will review research progress and controversies regarding the prognostic and functional significance of ACTN4 for tumorigenesis.
Identifiants
pubmed: 31766144
pii: cells8111427
doi: 10.3390/cells8111427
pmc: PMC6912194
pii:
doi:
Substances chimiques
ACTN4 protein, human
0
Biomarkers, Tumor
0
Proteome
0
Actinin
11003-00-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Oncogene. 2007 Aug 9;26(36):5290-9
pubmed: 17325659
Cancer Med. 2014 Jun;3(3):613-22
pubmed: 24574362
Oncogene. 2000 Jan 20;19(3):380-6
pubmed: 10656685
J Cell Sci. 2008 Mar 15;121(Pt 6):727-35
pubmed: 18322269
Biochim Biophys Acta Mol Cell Res. 2018 Jan;1865(1):196-208
pubmed: 29055790
Anticancer Res. 2014 Jun;34(6):3157-63
pubmed: 24922688
Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):29-39
pubmed: 30419315
Cancer Metastasis Rev. 2009 Jun;28(1-2):15-33
pubmed: 19169796
Cell Death Dis. 2018 Jun 4;9(6):668
pubmed: 29867145
Stem Cells. 2016 Aug;34(8):1997-2007
pubmed: 27251010
J Clin Invest. 2004 Aug;114(4):569-81
pubmed: 15314694
Brain Tumor Pathol. 2014 Jan;31(1):11-6
pubmed: 23504125
Cell Biosci. 2015 Aug 18;5:41
pubmed: 26288717
Cell Cycle. 2018;17(15):1917-1930
pubmed: 30109812
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4631-E4640
pubmed: 28533408
Eur Rev Med Pharmacol Sci. 2019 May;23(9):3838-3846
pubmed: 31115011
Lab Invest. 2017 Sep;97(9):1084-1094
pubmed: 28581489
Mol Cell Proteomics. 2007 Jan;6(1):114-24
pubmed: 17088265
J Biol Chem. 2012 Oct 12;287(42):35418-29
pubmed: 22908231
J Cell Sci. 2000 Sep;113 ( Pt 18):3329-40
pubmed: 10954430
Nephrol Dial Transplant. 2010 Mar;25(3):824-35
pubmed: 19666657
Front Oncol. 2015 Jul 20;5:155
pubmed: 26258068
J Biol Chem. 2015 Jan 2;290(1):338-49
pubmed: 25411248
Pancreatology. 2018 Sep;18(6):624-629
pubmed: 29921500
Ann Oncol. 2013 Oct;24(10):2594-600
pubmed: 23899839
Anticancer Res. 2015 Mar;35(3):1663-7
pubmed: 25750325
Lab Invest. 2008 Jun;88(6):602-14
pubmed: 18362906
Biomark Med. 2017 Sep;11(9):721-731
pubmed: 28658966
J Cell Biol. 1998 Mar 23;140(6):1383-93
pubmed: 9508771
Gastroenterology. 2005 Jan;128(1):51-62
pubmed: 15633123
Biochem J. 2013 Jun 15;452(3):477-88
pubmed: 23557398
Cell Death Differ. 2004 Jun;11(6):645-54
pubmed: 15002038
Med Sci Monit. 2019 May 04;25:3298-3302
pubmed: 31054253
Histopathology. 2012 Jun;60(7):1073-83
pubmed: 22348389
Exp Cell Res. 2017 Sep 1;358(1):78-85
pubmed: 28412244
Cell Cycle. 2018;17(5):616-626
pubmed: 29251177
Oncogene. 2018 Jul;37(29):4033-4045
pubmed: 29706658
Nat Rev Clin Oncol. 2017 Oct;14(10):611-629
pubmed: 28397828
Oncol Rep. 2013 Sep;30(3):1073-80
pubmed: 23817592
Biochim Biophys Acta Proteins Proteom. 2017 May;1865(5):488-498
pubmed: 28216224
Nat Genet. 2000 Mar;24(3):251-6
pubmed: 10700177
Tsitologiia. 2012;54(1):25-32
pubmed: 22567897
Mod Pathol. 2007 Dec;20(12):1278-85
pubmed: 17873890
Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42
pubmed: 16493418
Pathol Oncol Res. 2019 Mar 16;:null
pubmed: 30879239
PLoS One. 2009 Dec 23;4(12):e8427
pubmed: 20037648
J Exp Clin Cancer Res. 2017 Dec 02;36(1):172
pubmed: 29197410
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15014-9
pubmed: 17018644
Molecules. 2016 Jul 22;21(7):
pubmed: 27455225
Oncogene. 2004 Jul 1;23(30):5257-62
pubmed: 15122314
J Cell Sci. 2003 May 15;116(Pt 10):1959-67
pubmed: 12668723
Urology. 2010 Feb;75(2):357-64
pubmed: 19969329
J Cell Sci. 2001 Dec;114(Pt 23):4197-206
pubmed: 11739652
Br J Cancer. 2017 Aug 8;117(4):563-571
pubmed: 28664914
J Biol Chem. 2011 Jan 21;286(3):1850-9
pubmed: 21078666
J Exp Clin Cancer Res. 2017 Jan 26;36(1):19
pubmed: 28126034
Int J Oral Maxillofac Surg. 2017 Aug;46(8):968-976
pubmed: 28385383
Br J Cancer. 2015 Feb 17;112(4):704-13
pubmed: 25602965
Clin Cancer Res. 2003 Oct 15;9(13):4695-704
pubmed: 14581339
PLoS One. 2015 Apr 10;10(4):e0120616
pubmed: 25860875
J Biol Chem. 2014 Nov 21;289(47):32717-28
pubmed: 25296750
PLoS One. 2017 Jan 20;12(1):e0169622
pubmed: 28107418
Mol Cell Proteomics. 2007 Mar;6(3):479-91
pubmed: 17151021
Biochem Biophys Res Commun. 2010 Jun 25;397(2):192-6
pubmed: 20519146
FEBS J. 2014 Jul;281(13):2899-914
pubmed: 24802111
J Biol Chem. 2018 Oct 19;293(42):16528-16545
pubmed: 30166344
BMC Cancer. 2015 Apr 12;15:277
pubmed: 25885339
Cancer. 2007 Dec 15;110(12):2672-81
pubmed: 17960614
J Thorac Oncol. 2017 Jan;12(1):65-76
pubmed: 27613525
Nat Med. 2013 Nov;19(11):1438-49
pubmed: 24202396
Mol Med Rep. 2014 Nov;10(5):2433-40
pubmed: 25216292
Oncogene. 2016 Nov 10;35(45):5893-5904
pubmed: 27065319
Mod Pathol. 2009 Apr;22(4):499-507
pubmed: 19151661
Cancer Res. 2005 Oct 1;65(19):8836-45
pubmed: 16204054
PLoS One. 2010 Nov 11;5(11):e13921
pubmed: 21085685
J Immunol. 2006 Sep 15;177(6):4113-21
pubmed: 16951376
Exp Cell Res. 2010 Apr 15;316(7):1137-47
pubmed: 20156433
J Pathol. 2007 Sep;213(1):46-55
pubmed: 17668415
Med Oncol. 2013 Dec;30(4):697
pubmed: 23975634
Oncogene. 2013 Jan 24;32(4):462-70
pubmed: 22370640
Cell Biol Int. 2007 Apr;31(4):360-5
pubmed: 17336103
Clin Cancer Res. 2008 Sep 1;14(17):5348-56
pubmed: 18765526
J Thorac Oncol. 2015 Feb;10(2):286-301
pubmed: 25299231
Int J Oral Maxillofac Surg. 2010 Jan;39(1):61-7
pubmed: 19913389
PLoS One. 2011 Mar 08;6(3):e17179
pubmed: 21408150
Oncogene. 2004 Apr 8;23(15):2630-9
pubmed: 15048094
Glia. 2001 Dec;36(3):375-90
pubmed: 11746774
Oncotarget. 2013 Feb;4(2):362-72
pubmed: 23482348
Exp Cell Res. 2008 Mar 10;314(5):1030-8
pubmed: 18215660
Ann Oncol. 2013 Jan;24(1):84-90
pubmed: 22887464
J Physiol Biochem. 2019 Nov;75(4):475-487
pubmed: 31399951
J Biol Chem. 2005 Apr 15;280(15):15479-82
pubmed: 15710624
Cancer Lett. 2015 Aug 10;364(2):142-55
pubmed: 25960282
Pancreas. 2009 Nov;38(8):968-76
pubmed: 19672209
Cell. 2016 Jun 30;166(1):21-45
pubmed: 27368099
F1000Res. 2018 Sep 18;7:
pubmed: 30271576
Toxicol Appl Pharmacol. 2004 Sep 15;199(3):239-50
pubmed: 15364540
J Biol Chem. 2006 Nov 17;281(46):35070-80
pubmed: 16980305
Eur J Cell Biol. 2017 Oct;96(7):685-694
pubmed: 28797528
Oncotarget. 2016 May 31;7(22):33165-78
pubmed: 27121206
J Cell Sci. 2010 Apr 1;123(Pt 7):1020-30
pubmed: 20197409
FASEB J. 2016 Feb;30(2):578-89
pubmed: 26432781
Int J Biochem Cell Biol. 2018 Feb;95:73-84
pubmed: 29274473