Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.
China
Neurodevelopment
Organophosphate pesticides
Paraoxonase 1
Prenatal exposure
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
30
05
2019
accepted:
10
10
2019
pubmed:
27
11
2019
medline:
10
4
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
Prenatal organophosphate pesticide (OP) exposure was reported to negatively affect childhood neurodevelopment. Paraoxonase 1 (PON1) is a key enzyme in the metabolism of OPs and may affect an individual's susceptibility to OP exposure. However, little is known about its role in the associations of prenatal OP exposure and childhood neurodevelopment. We measured dimethylphosphate (DM), diethylphosphate (DE), and total dialkylphosphate (DAP) metabolites in maternal urine (n = 436) as well as PON1
Identifiants
pubmed: 31768953
doi: 10.1007/s11356-019-06740-4
pii: 10.1007/s11356-019-06740-4
doi:
Substances chimiques
Organophosphates
0
Pesticides
0
Aryldialkylphosphatase
EC 3.1.8.1
PON1 protein, human
EC 3.1.8.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1969-1977Subventions
Organisme : National Natural Science Foundation of China
ID : 81803185
Organisme : National Natural Science Foundation of China
ID : 81630085
Organisme : National Natural Science Foundation of China
ID : 81872629
Organisme : National Natural Science Foundation of China
ID : 81773387
Organisme : National Natural Science Foundation of China
ID : 81602823
Organisme : National Key Research and Development Program of China
ID : 2017YFC1600500
Organisme : National Key Research and Development Program of China
ID : 2016YFC1000203
Organisme : Scientific research program of Shanghai Municipal Commission of Health and Family Planning
ID : 201840180
Organisme : Scientific research program of Shanghai Municipal Commission of Health and Family Planning
ID : 201640174
Organisme : the Science and Technology Commission of Shanghai Municipality
ID : 17ZR1415800
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