PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology.


Journal

Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549

Informations de publication

Date de publication:
03 2020
Historique:
received: 23 10 2019
revised: 20 11 2019
accepted: 22 11 2019
pubmed: 27 11 2019
medline: 28 9 2021
entrez: 27 11 2019
Statut: ppublish

Résumé

Peroxisome proliferator-activated receptors (PPARs) are abundantly expressed in human skin, with PPAR-γ being the most intensively investigated isoform. In various ex vivo and in vivo models, PPAR-γ-mediated signalling has recently surfaced as an essential element of hair follicle (HF) development, growth and stem cell biology. Moreover, the availability of novel, topically applicable PPAR-γ modulators with a favourable toxicological profile has extended the range of potential applications in clinical dermatology. In this review, we synthesize where this field currently stands and sketch promising future research avenues, focussing on the role of PPAR-γ-mediated signalling in the biology and pathology of human scalp HFs, with special emphasis on scarring alopecias such as lichen planopilaris and frontal fibrosing alopecia as model human epithelial stem cell diseases. In particular, we discuss whether and how pharmacological modulation of PPAR-γ signalling may be employed for the management of hair growth disorders, for example, in scarring alopecia (by reducing HF inflammation as well as by promoting the survival and suppressing pathological epithelial-mesenchymal transition of keratin 15 + epithelial stem cells in the bulge) and in hirsutism/hypertrichosis (by promoting catagen development). Moreover, we explore the potential role of PPAR-γ in androgenetic alopecia, HF energy metabolism and HF ageing, and consider clinical perspectives that emanate from the limited data available on this so far. As this field of translational human hair research is still in its infancy, many open questions exist, for which we briefly delineate selected experimental approaches that promise to generate instructive answers in the near future.

Identifiants

pubmed: 31769892
doi: 10.1111/exd.14062
doi:

Substances chimiques

PPAR gamma 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

312-321

Subventions

Organisme : Monasterium Laboratory
Pays : International

Informations de copyright

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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Auteurs

Yuval Ramot (Y)

Department of Dermatology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Marta Bertolini (M)

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

Maria Boboljova (M)

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

Yoshikazu Uchida (Y)

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

Ralf Paus (R)

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Centre for Dermatology Research, University of Manchester, and NIHR Biomedical Research Centre, Manchester, UK.

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Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
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Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
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Humans Yoga Low Back Pain Female Male

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