Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Biomedical Research / methods Cardiovascular System / pathology Education / methods Heart Failure / diagnosis Humans Mitochondria / physiology National Heart, Lung, and Blood Institute (U.S.) / trends Research Report / trends Translational Research, Biomedical / methods United States / epidemiology
cardiovascular diseases heart failure mitochondria

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
01 10 2019
Historique:
entrez: 27 11 2019
pubmed: 27 11 2019
medline: 17 6 2020
Statut: ppublish

Résumé

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

Identifiants

DOI: 10.1161/CIRCULATIONAHA.119.040551 PMID: 31769940 PMC: PMC6880654
pubmed: 31769940
doi: 10.1161/CIRCULATIONAHA.119.040551
pmc: PMC6880654
mid: NIHMS1538376

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Pagination

1205-1216

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL052141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135736
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL064750
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130861
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125695
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136496
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126952
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 HL999999
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL126209
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM113816
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128349
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142628
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144778
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL058493
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134821
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108592
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138475
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100826
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129510
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144937
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL112730
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132075
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HV28178
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137266
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128071
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113057
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL049244
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 16GRNT27660006
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098646
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL061912
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL110349
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142864
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132525
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM086688
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137426
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124116
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137259
Pays : United States
Organisme : NIH HHS
ID : R01 OD010944
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122124
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063030
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL093671
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL092969
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103750
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS021328
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144509
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133003
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001430
Pays : United States

Informations de copyright

© 2019 American Heart Association, Inc.

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Auteurs

Rong Tian (R)

Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle.

Wilson S. Colucci (WS)

Department of Medicine, Boston University, MA.

Zoltan Arany (Z)

Department of Medicine, University of Pennsylvania, Philadelphia.

Markus M. Bachschmid (MM)

Department of Medicine, Boston University, MA.

Scott W. Ballinger (SW)

Department of Pathology, University of Alabama at Birmingham.

Sihem Boudina (S)

Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City.

James E. Bruce (JE)

Department of Genome Sciences, University of Washington, Seattle.

David W. Busija (DW)

Department of Pharmacology, Tulane University, New Orleans, LA.

Sergey Dikalov (S)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

Gerald W. Dorn (GW)

Center for Pharmacogenomics, Department of Internal Medicine, Washington University, St. Louis, MO.

Zorina S. Galis (ZS)

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Roberta A. Gottlieb (RA)

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

Daniel P. Kelly (DP)

Department of Medicine, University of Pennsylvania, Philadelphia.

Richard N. Kitsis (RN)

Department of Medicine, Department of Cell Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY.

Mark J. Kohr (MJ)

Departments of Environmental Health and Engineering, The Johns Hopkins University, Baltimore, MD.

Daniel Levy (D)

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

E. Douglas Lewandowski (ED)

Department of Internal Medicine, The Ohio State University, Columbus.

Joseph M. McClung (JM)

Department of Physiology, East Carolina University, Greenville, NC.

Daria Mochly-Rosen (D)

Department of Chemical and Systems Biology, Stanford University, CA.

Kevin D. O'Brien (KD)

Department of Medicine, University of Washington, Seattle.

Brian O'Rourke (B)

Department of Medicine, The Johns Hopkins University, Baltimore, MD.

Joon-Young Park (JY)

Department of Kinesiology, Temple University, Philadelphia, PA.

Peipei Ping (P)

Department of Physiology and Department of Medicine, University of California, Los Angeles.

Michael N. Sack (MN)

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Shey-Shing Sheu (SS)

Department of Medicine, Thomas Jefferson University, Philadelphia, PA.

Yang Shi (Y)

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Sruti Shiva (S)

Department of Pharmacology and Chemical Biology and Vascular Medicine Institute, University of Pittsburgh, PA.

Douglas C. Wallace (DC)

Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia Research Institute, PA.

Robert G. Weiss (RG)

Department of Medicine, The Johns Hopkins University, Baltimore, MD.

Hilary J. Vernon (HJ)

Department of Genetic Medicine, The Johns Hopkins University, Baltimore, MD.

Renee Wong (R)

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Lisa Schwartz Longacre (L)

National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Unlocking the Secrets of Mitochondria in the...
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