Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology.

Animals Blotting, Western Caloric Restriction Ghrelin / metabolism Glucagon-Like Peptide 1 / metabolism Leptin / metabolism Male Metabolome Mitochondria / metabolism Organelle Biogenesis Oxidative Stress Proton Magnetic Resonance Spectroscopy Random Allocation Rats Rats, Wistar Receptors, Leptin / metabolism Semen Analysis Sperm Head / pathology Spermatozoa / metabolism Testis / metabolism
caloric restriction hormonal profile male fertility testicular bioenergetics testis

Journal

American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226

Informations de publication

Date de publication:
01 01 2020
Historique:
pubmed: 27 11 2019
medline: 6 5 2020
entrez: 27 11 2019
Statut: ppublish

Résumé

Energy homeostasis is crucial for all physiological processes. Thus, when there is low energy intake, negative health effects may arise, including in reproductive function. We propose to study whether caloric restriction (CR) changes testicular metabolic profile and ultimately sperm quality. Male Wistar rats (

Identifiants

DOI: 10.1152/ajpendo.00355.2019 PMID: 31770015
pubmed: 31770015
doi: 10.1152/ajpendo.00355.2019
doi:

Substances chimiques

Ghrelin 0
Leptin 0
Receptors, Leptin 0
Glucagon-Like Peptide 1 89750-14-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

E33-E43

Auteurs

Ana D Martins (AD)

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (UMIB-ICBAS), University of Porto, Porto, Portugal.

Ivana Jarak (I)

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (UMIB-ICBAS), University of Porto, Porto, Portugal.

Tiago Morais (T)

Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (UMIB-ICBAS), University of Porto, Porto, Portugal.
Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

Rui A Carvalho (RA)

Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Portugal.

Pedro F Oliveira (PF)

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (UMIB-ICBAS), University of Porto, Porto, Portugal.
Department of Genetics, Faculty of Medicine, University of Porto, Porto, Portugal.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Mariana P Monteiro (MP)

Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (UMIB-ICBAS), University of Porto, Porto, Portugal.
Department of Anatomy, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Obesity and Bariatric Services and Centre for Obesity Research, University College of London Hospitals, UCL, London, United Kingdom.

Marco G Alves (MG)

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar (UMIB-ICBAS), University of Porto, Porto, Portugal.
ORCID: 0000-0001-7635-783X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Caloric restriction alters the hormonal...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Immunotransfert › Technique de Western › Caloric restriction alters the hormonal...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Ration calorique › Restriction calorique › Caloric restriction alters the hormonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Ghréline › Caloric restriction alters the hormonal...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Caloric restriction alters the hormonal...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Leptine › Caloric restriction alters the hormonal...
questionsmedicales.fr › Métabolisme › Métabolome › Caloric restriction alters the hormonal...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Caloric restriction alters the hormonal...
questionsmedicales.fr › Phénomènes biologiques › Biogenèse des organelles › Caloric restriction alters the hormonal...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Caloric restriction alters the hormonal...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Caloric restriction alters the hormonal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Caloric restriction alters the hormonal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Caloric restriction alters the hormonal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Caloric restriction alters the hormonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux adipokines › Récepteurs à la leptine › Caloric restriction alters the hormonal...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Analyse du sperme › Caloric restriction alters the hormonal...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Tête du spermatozoïde › Caloric restriction alters the hormonal...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Caloric restriction alters the hormonal...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Testicule › Caloric restriction alters the hormonal...