Asparaginase-Associated Pancreatitis in Acute Lymphoblastic Leukemia: Results From the NOPHO ALL2008 Treatment of Patients 1-45 Years of Age.
Adolescent
Adult
Antineoplastic Agents
/ administration & dosage
Asparaginase
/ administration & dosage
Child
Child, Preschool
Estonia
/ epidemiology
Female
Humans
Incidence
Infant
Lithuania
/ epidemiology
Male
Middle Aged
Pancreatitis
/ chemically induced
Polyethylene Glycols
/ administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Randomized Controlled Trials as Topic
Scandinavian and Nordic Countries
/ epidemiology
Young Adult
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
ISSN: 1527-7755
Titre abrégé: J Clin Oncol
Pays: United States
ID NLM: 8309333
Informations de publication
Date de publication:
10 01 2020
10 01 2020
Historique:
pubmed:
27
11
2019
medline:
26
6
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
Asparaginase-associated pancreatitis (AAP) is common in patients with acute lymphoblastic leukemia (ALL), but risk differences across age groups both in relation to first-time AAP and after asparaginase re-exposure have not been explored. We prospectively registered AAP (n = 168) during treatment of 2,448 consecutive ALL patients aged 1.0-45.9 years diagnosed from July 2008 to October 2018 and treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol. Compared with patients aged 1.0-9.9 years, adjusted AAP hazard ratios (HRa) were associated with higher age with almost identical HRa (1.6; 95% CI, 1.1 to 2.3; Older children and adults had similar AAP risk, whereas morbidity was most pronounced among adolescents. Asparaginase re-exposure should be considered only for patients with an anticipated high risk of leukemic relapse, because multiple studies strongly indicate that reduction of asparaginase treatment intensity increases the risk of relapse.
Identifiants
pubmed: 31770057
doi: 10.1200/JCO.19.02208
pmc: PMC6953441
doi:
Substances chimiques
Antineoplastic Agents
0
Polyethylene Glycols
3WJQ0SDW1A
pegaspargase
7D96IR0PPM
Asparaginase
EC 3.5.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-154Références
Lancet Oncol. 2015 Dec;16(16):1677-90
pubmed: 26549586
J Clin Oncol. 2013 Mar 20;31(9):1202-10
pubmed: 23358966
Eur J Cancer. 2014 Jan;50(2):251-9
pubmed: 24231337
Br J Haematol. 2013 Sep;162(5):710-3
pubmed: 23750892
Pediatr Hematol Oncol. 1998 Nov-Dec;15(6):533-8
pubmed: 9842647
Leukemia. 2018 Mar;32(3):606-615
pubmed: 28819280
Pediatr Blood Cancer. 2019 Jan;66(1):e27437
pubmed: 30216644
Lancet Oncol. 2016 Jun;17(6):e231-e239
pubmed: 27299279
J Clin Oncol. 2007 Mar 1;25(7):813-9
pubmed: 17327603
Crit Rev Oncol Hematol. 1998 Aug;28(2):97-113
pubmed: 9768345
J Clin Oncol. 2019 Jul 1;37(19):1638-1646
pubmed: 30978155
Clin Chem Lab Med. 2007;45(9):1140-4
pubmed: 17848118
Blood. 2014 Mar 27;123(13):2026-33
pubmed: 24449211
Lancet. 2008 Jan 12;371(9607):143-52
pubmed: 18191686
Gut. 2013 Jan;62(1):102-11
pubmed: 23100216
Lancet Oncol. 2014 Jul;15(8):809-18
pubmed: 24924991
Eur J Haematol. 2016 Feb;96(2):160-9
pubmed: 25867866
Cancer. 2011 Jan 15;117(2):238-49
pubmed: 20824725
Leukemia. 2017 Feb;31(2):325-332
pubmed: 27451978
Haematologica. 2019 Mar;104(3):556-563
pubmed: 30467200
Metabolism. 2009 Sep;58(9):1256-62
pubmed: 19497594
Br J Haematol. 2012 Oct;159(1):18-27
pubmed: 22909259
Int J Obes Relat Metab Disord. 2001 Feb;25(2):177-84
pubmed: 11410817
J Clin Oncol. 2008 Apr 10;26(11):1843-9
pubmed: 18398150
Blood. 2002 Apr 15;99(8):2734-9
pubmed: 11929760
N Engl J Med. 1998 Jun 4;338(23):1663-71
pubmed: 9614257
J Clin Oncol. 2016 Jun 20;34(18):2133-40
pubmed: 27114598
N Engl J Med. 2016 Nov 17;375(20):1972-1981
pubmed: 27959604
J Pediatr Hematol Oncol. 2009 Oct;31(10):790-3
pubmed: 19770681
Leuk Lymphoma. 2011 Dec;52(12):2237-53
pubmed: 21827361
World J Gastroenterol. 2006 Sep 21;12(35):5705-10
pubmed: 17007026
Pediatr Blood Cancer. 2017 Dec;64(12):
pubmed: 28660740
Br J Haematol. 2014 Apr;165(1):126-33
pubmed: 24428625
Arch Surg. 1993 May;128(5):586-90
pubmed: 8489394
Blood. 2001 Mar 1;97(5):1211-8
pubmed: 11222362
Pediatr Blood Cancer. 2007 Oct 15;49(5):634-9
pubmed: 16937362
Pediatr Blood Cancer. 2009 Aug;53(2):162-7
pubmed: 19405141
Blood. 2007 Feb 1;109(3):896-904
pubmed: 17003366
Pancreat Disord Ther. 2013 Apr 1;3(1):112
pubmed: 24808987
Leukemia. 2015 Mar;29(3):526-34
pubmed: 25079173
Blood. 2018 May 31;131(22):2475-2484
pubmed: 29661787
Lancet Oncol. 2017 Sep;18(9):1238-1248
pubmed: 28736188
Eur J Haematol. 2013 May;90(5):404-12
pubmed: 23461707