Changes in vascular density in resected tissue of 97 patients with mild malformation of cortical development, focal cortical dysplasia or TSC-related cortical tubers.
Adolescent
Adult
Cerebral Cortex
/ pathology
Child
Child, Preschool
Epilepsy
/ pathology
Female
Humans
Infant
Male
Malformations of Cortical Development
/ pathology
Malformations of Cortical Development, Group I
/ pathology
Microvessels
/ pathology
Middle Aged
Tuberous Sclerosis
/ pathology
Young Adult
Epilepsy surgery
Focal cortical dysplasia
Mild malformation of cortical development
Refractory epilepsy
Tuberous sclerosis complex
Vascular density
Journal
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
ISSN: 1873-474X
Titre abrégé: Int J Dev Neurosci
Pays: United States
ID NLM: 8401784
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
18
02
2019
revised:
13
10
2019
accepted:
22
11
2019
pubmed:
27
11
2019
medline:
12
5
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
Recent studies suggested a possible association between malformations of cortical development and microvascular density. In this study we aimed to further elucidate the relation between microvascular density and cortical developmental abnormalities in a cohort of 97 patients with epilepsy and histologically proven mild malformation of cortical development (mMCD), focal cortical dysplasia (FCD) or tuberous sclerosis complex (TSC). Surgical tissue samples were analyzed with quantitative measures of vessel density, T-cell response, microglial activation and myelin content. Subsequently, the results were compared to an age- and localization matched control group. We observed an increase in microvasculature in white matter of TSC cortical tubers, which is linked to inflammatory response. No increase was seen in mMCD or FCD subtypes compared to controls. In mMCD/FCD and tubers, lesional cortex and white matter showed increased vascular density compared to perilesional tissues. Moreover, cortical vessel density increased with longer epilepsy duration and older age at surgery while in controls it decreased with age. Our findings suggest for that the increase in white matter vascular density might be pathology-specific rather than a consequence of ongoing epileptic activity. Increased cortical vessel density with age and with longer epilepsy duration in mMCD/FCD's and tubers, however, could be a consequence of seizures.
Identifiants
pubmed: 31770571
doi: 10.1016/j.ijdevneu.2019.11.003
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-104Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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