A Calcium-Rich Multimineral Intervention to Modulate Colonic Microbial Communities and Metabolomic Profiles in Humans: Results from a 90-Day Trial.
Adult
Aged
Bile Acids and Salts
/ analysis
Calcium Carbonate
/ administration & dosage
Colon
/ drug effects
Colonic Neoplasms
/ microbiology
DNA, Bacterial
/ isolation & purification
Dietary Supplements
/ adverse effects
Fatty Acids, Volatile
/ analysis
Feces
/ chemistry
Female
Gastrointestinal Microbiome
/ drug effects
Healthy Volunteers
Humans
Intestinal Mucosa
/ drug effects
Kidney
/ drug effects
Liver
/ drug effects
Male
Metabolomics
Middle Aged
Minerals
/ administration & dosage
Pilot Projects
Young Adult
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
27
06
2019
revised:
02
08
2019
accepted:
22
11
2019
pubmed:
28
11
2019
medline:
1
4
2021
entrez:
28
11
2019
Statut:
ppublish
Résumé
Aquamin is a calcium-, magnesium-, and multiple trace element-rich natural product with colon polyp prevention efficacy based on preclinical studies. The goal of this study was to determine the effects of Aquamin on colonic microbial community and attendant metabolomic profile. Thirty healthy human participants were enrolled in a 90-day trial in which Aquamin (delivering 800 mg of calcium per day) was compared with calcium alone or placebo. Before and after the intervention, colonic biopsies and stool specimens were obtained. All 30 participants completed the study without serious adverse event or change in liver and renal function markers. Compared with pretreatment values, intervention with Aquamin led to a reduction in total bacterial DNA (
Identifiants
pubmed: 31771942
pii: 1940-6207.CAPR-19-0325
doi: 10.1158/1940-6207.CAPR-19-0325
pmc: PMC7528938
mid: NIHMS1625867
doi:
Substances chimiques
Aquamin
0
Bile Acids and Salts
0
DNA, Bacterial
0
Fatty Acids, Volatile
0
Minerals
0
Calcium Carbonate
H0G9379FGK
Types de publication
Clinical Trial, Phase I
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-116Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002241
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA201782
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002242
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
Références
Cancer Res. 2001 Apr 15;61(8):3465-71
pubmed: 11309309
Mutat Res. 2005 Jan;589(1):47-65
pubmed: 15652226
Gastroenterology. 2016 Jan;150(1):114-122.e4
pubmed: 26404953
J Lipid Res. 2010 Jan;51(1):23-41
pubmed: 20008121
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Gastroenterology. 1990 Dec;99(6):1653-9
pubmed: 2121581
Sci Transl Med. 2013 Jun 19;5(190):190ra81
pubmed: 23785037
Nat Rev Microbiol. 2014 Oct;12(10):661-72
pubmed: 25198138
mSphere. 2017 Mar 8;2(2):
pubmed: 28289728
Nature. 2016 Apr 7;532(7597):117-21
pubmed: 27027293
Appl Environ Microbiol. 2013 Sep;79(17):5112-20
pubmed: 23793624
Carcinogenesis. 2009 Jan;30(1):88-92
pubmed: 19017685
J Pediatr Surg. 2016 Jan;51(1):81-6
pubmed: 26561246
Nat Rev Microbiol. 2013 Jun;11(6):371-84
pubmed: 23669886
Cancer Prev Res (Phila). 2018 Jul;11(7):413-428
pubmed: 29636350
Integr Cancer Ther. 2010 Mar;9(1):93-9
pubmed: 20150219
Mol Carcinog. 2015 Jul;54(7):543-53
pubmed: 26076051
Biol Trace Elem Res. 2012 Jun;147(1-3):267-74
pubmed: 22222483
Mar Drugs. 2018 Jun 20;16(6):
pubmed: 29925774
Gut. 2019 Mar;68(3):475-486
pubmed: 29496722
N Engl J Med. 2015 Oct 15;373(16):1519-30
pubmed: 26465985
Appl Environ Microbiol. 2009 Dec;75(23):7537-41
pubmed: 19801464
Mol Nutr Food Res. 2016 Feb;60(2):468-80
pubmed: 26582185
J Clin Invest. 2016 Dec 1;126(12):4430-4443
pubmed: 27775551
Biometals. 2004 Jun;17(3):189-96
pubmed: 15222464
Nutr Cancer. 2012;64(7):1020-8
pubmed: 23035966
Annu Rev Microbiol. 2016 Sep 8;70:395-411
pubmed: 27607555
J Antimicrob Chemother. 2008 Feb;61(2):353-61
pubmed: 18070832
Cancer Lett. 2009 Oct 8;283(2):186-92
pubmed: 19394137
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
Nat Microbiol. 2017 Feb 13;2:17004
pubmed: 28191884
Appl Environ Microbiol. 1999 Jul;65(7):3158-63
pubmed: 10388717
BMJ. 2010 Jul 29;341:c3691
pubmed: 20671013
Front Microbiol. 2016 Feb 17;7:185
pubmed: 26925050
Therap Adv Gastroenterol. 2013 May;6(3):215-29
pubmed: 23634186
Int J Cancer. 2014 Oct 15;135(8):1940-8
pubmed: 24623471
Biochim Biophys Acta. 2013 Sep;1828(9):2152-63
pubmed: 23747364
Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):392-399
pubmed: 30464021
PLoS One. 2016 Nov 16;11(11):e0166178
pubmed: 27851786
Cell Metab. 2016 Jul 12;24(1):41-50
pubmed: 27320064
Curr Protoc Immunol. 2011 Nov;Chapter 14:Unit 14.26
pubmed: 22048801
PLoS One. 2013 Aug 19;8(8):e71806
pubmed: 23977147
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Ann N Y Acad Sci. 1999;889:138-45
pubmed: 10668490
PLoS One. 2019 Apr 17;14(4):e0215122
pubmed: 30995271
J Nutr. 2014 Mar;144(3):297-304
pubmed: 24453130
Trends Microbiol. 2019 Feb;27(2):105-117
pubmed: 30497919
Nutr J. 2009 Feb 02;8:7
pubmed: 19187557
Microbes Infect. 2007 Nov-Dec;9(14-15):1662-70
pubmed: 18024118
Nutr J. 2008 Feb 17;7:9
pubmed: 18279523
J Natl Cancer Inst. 2003 Dec 3;95(23):1765-71
pubmed: 14652238