A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation.

autoinflammatory syndrome bradykinin coagulation factor enzyme mutation factor XII hereditary angioedema inflammation kringle domain serine protease vascular biology

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
10 01 2020
Historique:
received: 13 06 2019
revised: 20 11 2019
pubmed: 28 11 2019
medline: 15 9 2020
entrez: 28 11 2019
Statut: ppublish

Résumé

Coagulation factor XII (FXII) drives production of the inflammatory peptide bradykinin. Pathological mutations in the

Identifiants

pubmed: 31771982
pii: S0021-9258(17)48333-5
doi: 10.1074/jbc.RA119.009788
pmc: PMC6956518
pii:
doi:

Substances chimiques

Factor XII 9001-30-3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

363-374

Informations de copyright

© 2020 Hofman et al.

Références

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Auteurs

Zonne L M Hofman (ZLM)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands; Laboratory for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

Chantal C Clark (CC)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.

Wariya Sanrattana (W)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.

Aziz Nosairi (A)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.

Naomi M J Parr (NMJ)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.

Minka Živkovic (M)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.

Karoline Krause (K)

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Niklas A Mahnke (NA)

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Jörg Scheffel (J)

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

C Erik Hack (CE)

Laboratory for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

Marcus Maurer (M)

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Steven de Maat (S)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.

Coen Maas (C)

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands. Electronic address: cmaas4@umcutrecht.nl.

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Classifications MeSH