Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia.

Animals Anti-Bacterial Agents / therapeutic use Bacteremia / drug therapy Cefazolin / therapeutic use Ertapenem Methicillin / pharmacology Rats Salvage Therapy Staphylococcal Infections / drug therapy Staphylococcus aureus
Staphylococcus aureus bacteremia cefazolin endocarditis ertapenem

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
12 09 2020
Historique:
received: 20 05 2019
accepted: 20 10 2019
pubmed: 28 11 2019
medline: 28 4 2021
entrez: 28 11 2019
Statut: ppublish

Résumé

Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.

Identifiants

DOI: 10.1093/cid/ciz995 PMID: 31773134 PMC: PMC7486850
pubmed: 31773134
pii: 5644098
doi: 10.1093/cid/ciz995
pmc: PMC7486850
doi:

Substances chimiques

Anti-Bacterial Agents 0
Ertapenem G32F6EID2H
Cefazolin IHS69L0Y4T
Methicillin Q91FH1328A

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1413-1418

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD090259
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI124316
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090259
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI151253
Pays : United States

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Auteurs

Erlinda R Ulloa (ER)

Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.
Division of Infectious Disease, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Kavindra V Singh (KV)

Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Matthew Geriak (M)

Sharp Memorial Hospital, San Diego, California, USA.

Fadi Haddad (F)

Sharp Grossmont Hospital, La Mesa, California, USA.

Barbara E Murray (BE)

Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Victor Nizet (V)

Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.
Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California, USA.

George Sakoulas (G)

Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.
Sharp Memorial Hospital, San Diego, California, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Bactériémie › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfazoline › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Ertapénem › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Méticilline › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Thérapeutique › Thérapie de rattrapage › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à staphylocoques › Cefazolin and Ertapenem Salvage Therapy...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Cefazolin and Ertapenem Salvage Therapy...