Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation.
Anti-Retroviral Agents
/ pharmacology
Cell Line
Down-Regulation
Drug Development
HIV-1
/ drug effects
Histocompatibility Antigens Class I
/ genetics
Humans
Inhibitory Concentration 50
Leukocytes, Mononuclear
/ virology
Pyrazoles
/ pharmacology
Tissue Donors
Virus Replication
/ drug effects
nef Gene Products, Human Immunodeficiency Virus
/ antagonists & inhibitors
HIV accessory proteins
HIV-1 Nef inhibitors
HIV/AIDS
antiretroviral drug development
surface plasmon resonance
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
14 02 2020
14 02 2020
Historique:
pubmed:
30
11
2019
medline:
12
1
2021
entrez:
29
11
2019
Statut:
ppublish
Résumé
The HIV-1 Nef accessory factor is critical to the viral life cycle
Identifiants
pubmed: 31775511
doi: 10.1021/acsinfecdis.9b00382
pmc: PMC8142392
mid: NIHMS1584440
doi:
Substances chimiques
Anti-Retroviral Agents
0
Histocompatibility Antigens Class I
0
Pyrazoles
0
nef Gene Products, Human Immunodeficiency Virus
0
nef protein, Human immunodeficiency virus 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
302-312Subventions
Organisme : NIAID NIH HHS
ID : R01 AI057083
Pays : United States
Organisme : NIGMS NIH HHS
ID : R41 GM112516
Pays : United States
Organisme : NIGMS NIH HHS
ID : R42 GM112516
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152677
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126617
Pays : United States
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