Astrovirus Replication Is Inhibited by Nitazoxanide
antiviral agents
astrovirus
diarrhea
viral replication
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
14 02 2020
14 02 2020
Historique:
received:
07
10
2019
accepted:
25
11
2019
pubmed:
30
11
2019
medline:
22
8
2020
entrez:
29
11
2019
Statut:
epublish
Résumé
Astroviruses (AstV) are a leading cause of diarrhea, especially in the very young, the elderly, and immunocompromised populations. Despite their significant impact on public health, no drug therapies for astrovirus have been identified. In this study, we fill this gap in knowledge and demonstrate that the FDA-approved broad-spectrum anti-infective drug nitazoxanide (NTZ) blocks astrovirus replication
Identifiants
pubmed: 31776285
pii: JVI.01706-19
doi: 10.1128/JVI.01706-19
pmc: PMC7022343
pii:
doi:
Substances chimiques
Nitro Compounds
0
Thiazoles
0
nitazoxanide
SOA12P041N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI135254
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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