Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats.
Acetaminophen
/ adverse effects
Alanine Transaminase
/ blood
Animals
Anti-Inflammatory Agents
/ pharmacology
Antioxidants
/ pharmacology
Aspartate Aminotransferases
/ blood
Chemical and Drug Induced Liver Injury
/ drug therapy
Creatinine
/ blood
Cytokines
/ metabolism
Flavones
/ pharmacology
Glutathione
/ metabolism
Glutathione Peroxidase
/ metabolism
Heme Oxygenase (Decyclizing)
/ metabolism
Kidney
/ drug effects
Liver
/ drug effects
Male
Malondialdehyde
/ metabolism
NF-E2-Related Factor 2
/ metabolism
Oxidative Stress
/ drug effects
Rats
Rats, Wistar
Urea
/ blood
Nrf-2/HO-1
acetaminophen
nobiletin
oxidative stress
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
08
05
2019
revised:
22
09
2019
accepted:
15
11
2019
pubmed:
30
11
2019
medline:
27
2
2020
entrez:
29
11
2019
Statut:
ppublish
Résumé
The study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of experiment; the Nobiletin group (group 3), nobiletin (10 mg/kg) for 10 days; and the APAP + Nobiletin group (group 4), nobiletin (10 mg/kg) for 10 days with a single dose of APAP (1000 mg/kg) administered on the 10th day and the experiment ended after 48 hours. At the end of the study, a significant increase in malondialdehyde, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels and a significant decrease in glutathione levels, glutathione peroxidase activities and nuclear factor erythroid-derived 2-like 2 (Nrf-2) and heme oxygenase-1 (HO-1) expressions were observed with APAP application in liver and kidney tissues. Serum aspartate transaminase (AST), alanine transaminase (ALT), urea, and creatinine levels were also significantly increased in the APAP group. However, nobiletin treatment in group 4 reversed oxidative stress and inflammatory and histopathological signs caused by APAP. It is concluded that nobiletin may be a beneficial substance that confers hepatorenal protection to APAP-induced toxicity via antioxidant and anti-inflammatory mechanisms.
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Cytokines
0
Flavones
0
NF-E2-Related Factor 2
0
Nfe2l2 protein, rat
0
Acetaminophen
362O9ITL9D
Malondialdehyde
4Y8F71G49Q
Urea
8W8T17847W
Creatinine
AYI8EX34EU
nobiletin
D65ILJ7WLY
Glutathione Peroxidase
EC 1.11.1.9
Heme Oxygenase (Decyclizing)
EC 1.14.14.18
Hmox1 protein, rat
EC 1.14.14.18
Aspartate Aminotransferases
EC 2.6.1.1
Alanine Transaminase
EC 2.6.1.2
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22427Subventions
Organisme : Mustafa Kemal Üniversitesi
ID : 17.M.006
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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