Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function.
Amino Acid Sequence
Cell Membrane
/ metabolism
Enzyme Activation
Gene Expression
Genes, Reporter
Humans
Intracellular Space
Models, Biological
PTEN Phosphohydrolase
/ chemistry
Protein Binding
Protein Interaction Domains and Motifs
Protein Transport
Saccharomyces cerevisiae
/ genetics
Structure-Activity Relationship
Yeasts
/ genetics
PI3K
PTEN
Saccharomyces cerevisiae
alternative translation initiation
heterologous expression
phosphoinositides
subcellular localization
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
received:
31
10
2019
revised:
21
11
2019
accepted:
22
11
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
25
7
2020
Statut:
epublish
Résumé
The tumour suppressor PTEN is frequently downregulated, mutated or lost in several types of tumours and congenital disorders including PHTS (PTEN Hamartoma Tumour Syndrome) and ASD (Autism Spectrum Disorder). PTEN is a lipid phosphatase whose activity over the lipid messenger PIP
Identifiants
pubmed: 31779149
pii: cells8121512
doi: 10.3390/cells8121512
pmc: PMC6952770
pii:
doi:
Substances chimiques
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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