Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor.
Adaptation, Psychological
Adolescent
Adult
Antineoplastic Agents
/ adverse effects
Brain Neoplasms
/ pathology
Cancer Survivors
/ psychology
Child
Child, Preschool
Cisplatin
/ adverse effects
Combined Modality Therapy
Craniospinal Irradiation
/ adverse effects
Cross-Sectional Studies
Female
Follow-Up Studies
Hearing Loss, Sensorineural
/ physiopathology
Humans
Male
Neurocognitive Disorders
/ etiology
Prognosis
Young Adult
Adaptive
Cognitive
Embryonal brain tumor
Medulloblastoma
Pediatric
Sensorineural hearing loss
Journal
Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
27
09
2019
accepted:
25
11
2019
pubmed:
30
11
2019
medline:
10
6
2020
entrez:
30
11
2019
Statut:
ppublish
Résumé
Survivors of pediatric embryonal brain tumors (BT) are at high risk for sensorineural hearing loss (SNHL) associated with neurocognitive decline. However, previous studies have not assessed the relationship between SNHL and adaptive functioning. We examined neurocognitive and adaptive functioning in patients with and without SNHL. Participants included 36 patients treated for an embryonal BT with craniospinal irradiation (CSI) and cisplatin chemotherapy who were assessed 6.7 years post-treatment on average. The impact of SNHL on neurocognitive performance and parent-rated adaptive functioning was assessed in univariate and multivariate analyses. There were 17 cases with SNHL (mean age at evaluation = 14.4) and 19 cases with NH (mean age at evaluation = 13.8). After accounting for age at diagnosis and additional covariates in multivariable analyses, SNHL was associated with worse overall intellectual functioning (p = 0.027) and perceptual reasoning (p = 0.016) performance. There was no effect of SNHL on adaptive functioning in multivariable models. Age at diagnosis and sex were associated with performance on neurocognitive measures. SNHL in pediatric embryonal BT is associated with increased risk for neurocognitive deficits in conjunction with other demographic and treatment-related factors.
Identifiants
pubmed: 31782051
doi: 10.1007/s11060-019-03356-z
pii: 10.1007/s11060-019-03356-z
pmc: PMC6939134
mid: NIHMS1544907
doi:
Substances chimiques
Antineoplastic Agents
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-156Subventions
Organisme : Division of Cancer Prevention, National Cancer Institute
ID : R01CA187202
Organisme : NCI NIH HHS
ID : R01 CA187202
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA157923
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA221197
Pays : United States
Organisme : Division of Cancer Prevention, National Cancer Institute
ID : K07CA157923
Organisme : Division of Cancer Prevention, National Cancer Institute
ID : R01CA221197
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