Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.

Animals Choline / pharmacology Cyclic GMP / metabolism Dinoprostone / metabolism Freund's Adjuvant Hyperalgesia / drug therapy Inflammation / drug therapy KATP Channels / metabolism Male Mice Mice, Inbred BALB C Nitric Oxide / metabolism alpha7 Nicotinic Acetylcholine Receptor / agonists
Alpha 7-nicotinic acetylcholine receptor Choline Hyperalgesia Inflammation Neuroimmunomodulation

Journal

Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503

Informations de publication

Date de publication:
15 01 2020
Historique:
received: 01 11 2018
revised: 18 11 2019
accepted: 23 11 2019
pubmed: 30 11 2019
medline: 11 3 2021
entrez: 30 11 2019
Statut: ppublish

Résumé

New findings on neural regulation of immunity are allowing the design of novel pharmacological strategies to control inflammation and nociception. Herein, we report that choline, a 7-nicotinic acetylcholine receptor (α7nAChRs) agonist, prevents carrageenan-induced hyperalgesia without affecting inflammatory parameters (neutrophil migration or cytokine/chemokines production) or inducing sedation or even motor impairment. Choline also attenuates prostaglandin-E

Identifiants

DOI: 10.1016/j.brainres.2019.146567 PMID: 31783002 PMC: PMC7054728
pubmed: 31783002
pii: S0006-8993(19)30621-3
doi: 10.1016/j.brainres.2019.146567
pmc: PMC7054728
mid: NIHMS1556093
pii:
doi:

Substances chimiques

KATP Channels 0
alpha7 Nicotinic Acetylcholine Receptor 0
Nitric Oxide 31C4KY9ESH
Freund's Adjuvant 9007-81-2
Cyclic GMP H2D2X058MU
Dinoprostone K7Q1JQR04M
Choline N91BDP6H0X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

146567

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM114180
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

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Auteurs

Ricardo Kusuda (R)

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Eleonora Uchôa Carreira (EU)

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Luis Ulloa (L)

Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University, Durham, NC 27710, USA.

Fernando Queiroz Cunha (FQ)

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Alexandre Kanashiro (A)

Department of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Thiago Mattar Cunha (TM)

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Electronic address: thicunha@fmrp.usp.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Choline › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › GMP cyclique › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Mélanges complexes › Adjuvant Freund › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles somatosensoriels › Hyperalgésie › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Canaux KATP › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Choline attenuates inflammatory hyperalgesia...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Récepteur nicotinique de l'acétylcholine alpha7 › Choline attenuates inflammatory hyperalgesia...