Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration.
Animals
Body Size
Cell Adhesion Molecules, Neuronal
/ physiology
Cell Proliferation
Endothelium
/ cytology
Female
Hepatectomy
Hepatocyte Growth Factor
/ physiology
Hepatocytes
/ cytology
Homeostasis
Liver Diseases
/ metabolism
Liver Regeneration
Male
Mice
Mice, Knockout
Organogenesis
/ physiology
Paracrine Communication
Signal Transduction
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
23
04
2019
revised:
11
10
2019
accepted:
22
10
2019
pubmed:
30
11
2019
medline:
6
5
2020
entrez:
30
11
2019
Statut:
ppublish
Résumé
Liver sinusoidal endothelial cells (LSECs) control organ functions, metabolism, and development through the secretion of angiokines. LSECs express hepatocyte growth factor (Hgf), which is involved in prenatal development, metabolic homeostasis, and liver regeneration. This study aimed to elucidate the precise contribution of LSEC-derived Hgf in physiological homeostasis and liver regeneration. Stab2-iCre
Identifiants
pubmed: 31783007
pii: S0002-9440(19)30846-6
doi: 10.1016/j.ajpath.2019.10.009
pii:
doi:
Substances chimiques
Cell Adhesion Molecules, Neuronal
0
HGF protein, mouse
0
Stab2 protein, mouse
0
Hepatocyte Growth Factor
67256-21-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
358-371Informations de copyright
Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.