Multifunctional calcium phosphate based coatings on titanium implants with integrated trace elements.
Anti-Infective Agents
/ chemistry
Bacterial Adhesion
/ drug effects
Calcium Phosphates
/ chemistry
Cell Adhesion
Coated Materials, Biocompatible
/ chemistry
Copper
/ chemistry
Drug Resistance, Microbial
Escherichia coli
/ drug effects
Human Umbilical Vein Endothelial Cells
Humans
Ions
Materials Testing
Mesenchymal Stem Cells
/ drug effects
Microbial Sensitivity Tests
Neovascularization, Physiologic
Osseointegration
/ drug effects
Osteogenesis
/ drug effects
Prostheses and Implants
Prosthesis Design
Titanium
/ chemistry
Trace Elements
/ chemistry
X-Ray Diffraction
Zinc
/ chemistry
Journal
Biomedical materials (Bristol, England)
ISSN: 1748-605X
Titre abrégé: Biomed Mater
Pays: England
ID NLM: 101285195
Informations de publication
Date de publication:
27 02 2020
27 02 2020
Historique:
pubmed:
30
11
2019
medline:
15
5
2021
entrez:
30
11
2019
Statut:
epublish
Résumé
For decades, the main focus of titanium implants developed to restore bone functionality was on improved osseointegration. Additional antimicrobial properties have now become desirable, due to the risk that rising antibiotic resistance poses for implant-associated infections. To this end, the trace elements of copper and zinc were integrated into calcium phosphate based coatings by electrochemically assisted deposition. In addition to their antimicrobial activity, zinc is reported to attract bone progenitor cells through chemotaxis and thus increase osteogenic differentiation, and copper to stimulate angiogenesis. Quantities of up to 68.9 ± 0.1 μg cm
Identifiants
pubmed: 31783394
doi: 10.1088/1748-605X/ab5d7b
doi:
Substances chimiques
Anti-Infective Agents
0
Calcium Phosphates
0
Coated Materials, Biocompatible
0
Ions
0
Trace Elements
0
Copper
789U1901C5
calcium phosphate
97Z1WI3NDX
Titanium
D1JT611TNE
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM