Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways.
A549 Cells
Antineoplastic Agents
/ pharmacology
Cell Survival
/ drug effects
DNA Damage
G2 Phase Cell Cycle Checkpoints
/ drug effects
Hep G2 Cells
Humans
Lanatosides
/ pharmacology
M Phase Cell Cycle Checkpoints
/ drug effects
MCF-7 Cells
Neoplasms
/ drug therapy
Phosphatidylinositol 3-Kinases
/ metabolism
Phosphoinositide-3 Kinase Inhibitors
/ pharmacology
Protein Kinase Inhibitors
/ pharmacology
Protein Kinases
/ metabolism
Signal Transduction
/ drug effects
Wnt Proteins
/ antagonists & inhibitors
Cardiac glycosides
G2/M phase
Na+/k+-ATPase
apoptosis
autophagy
molecular docking
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
27 11 2019
27 11 2019
Historique:
received:
21
10
2019
revised:
22
11
2019
accepted:
22
11
2019
entrez:
1
12
2019
pubmed:
1
12
2019
medline:
12
9
2020
Statut:
epublish
Résumé
Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of ubiquitous transmembrane protein Na
Identifiants
pubmed: 31783627
pii: biom9120792
doi: 10.3390/biom9120792
pmc: PMC6995510
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Lanatosides
0
Phosphoinositide-3 Kinase Inhibitors
0
Protein Kinase Inhibitors
0
Wnt Proteins
0
lanatoside C
5RR3JFZ771
Protein Kinases
EC 2.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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