Age-dependent hemato- and nephrotoxicity in patients with head and neck cancer receiving chemoradiotherapy with weekly cisplatin.
Altersabhängige Hämato- und Nephrotoxizität bei Patienten mit Kopf-Hals-Tumoren unter Radiochemotherapie mit wöchentlicher Cisplatin-Gabe.
Acute Kidney Injury
/ chemically induced
Adolescent
Adult
Age Factors
Aged
Antineoplastic Agents, Alkylating
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Chemoradiotherapy
/ adverse effects
Cisplatin
/ administration & dosage
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Head and Neck Neoplasms
/ mortality
Heavy Ion Radiotherapy
Humans
Kaplan-Meier Estimate
Leukopenia
/ chemically induced
Lymphatic Irradiation
Lymphatic Metastasis
/ therapy
Male
Middle Aged
Progression-Free Survival
Radiotherapy, Intensity-Modulated
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
/ mortality
Treatment Outcome
Young Adult
Compliance
Cumulative dose
Head and neck neoplasms
Kidney injury
Leukopenia
Survival
Journal
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
ISSN: 1439-099X
Titre abrégé: Strahlenther Onkol
Pays: Germany
ID NLM: 8603469
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
06
05
2019
accepted:
06
11
2019
pubmed:
1
12
2019
medline:
15
12
2020
entrez:
1
12
2019
Statut:
ppublish
Résumé
In cases of simultaneous chemoradiotherapy (CRT), early recognition of toxic side effects is important, as drug discontinuation may prevent further injury. It appears favorable to undertake further steps to investigate whether patient subgroups behave differently depending on their toxicity profile. We retrospectively analyzed 125 consecutive patients with non-metastasized carcinoma of the head and neck who were treated with CRT (cisplatin 40 mg/m Eighty-six patients did not reach the intended sixth cycle (68.8%; 60.0% of whom were ≥60 years, p < 0.05). Acute kidney injury (glomerular filtration rate <60 mL/min/1.73m Acute kidney injury was the most common side effect in patients ≥60 years, whereas leukopenia characteristically occurred significantly more often in younger patients. Discontinuing cisplatin during CRT was associated with a worse outcome, especially in patients <60 years.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
In cases of simultaneous chemoradiotherapy (CRT), early recognition of toxic side effects is important, as drug discontinuation may prevent further injury. It appears favorable to undertake further steps to investigate whether patient subgroups behave differently depending on their toxicity profile.
METHODS
METHODS
We retrospectively analyzed 125 consecutive patients with non-metastasized carcinoma of the head and neck who were treated with CRT (cisplatin 40 mg/m
RESULTS
RESULTS
Eighty-six patients did not reach the intended sixth cycle (68.8%; 60.0% of whom were ≥60 years, p < 0.05). Acute kidney injury (glomerular filtration rate <60 mL/min/1.73m
CONCLUSION
CONCLUSIONS
Acute kidney injury was the most common side effect in patients ≥60 years, whereas leukopenia characteristically occurred significantly more often in younger patients. Discontinuing cisplatin during CRT was associated with a worse outcome, especially in patients <60 years.
Identifiants
pubmed: 31784802
doi: 10.1007/s00066-019-01550-6
pii: 10.1007/s00066-019-01550-6
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM