Isoliquiritigenin inhibits melanogenesis, melanocyte dendricity and melanosome transport by regulating ERK-mediated MITF degradation.
Adrenocorticotropic Hormone
/ pharmacology
Cell Line, Tumor
Chalcones
/ pharmacology
Enzyme Inhibitors
/ pharmacology
Humans
Intramolecular Oxidoreductases
/ metabolism
Keratinocytes
/ metabolism
MAP Kinase Signaling System
/ drug effects
Male
Melanins
/ biosynthesis
Melanocytes
/ drug effects
Microphthalmia-Associated Transcription Factor
/ metabolism
Monophenol Monooxygenase
/ metabolism
Protein Biosynthesis
/ drug effects
Protein Transport
/ drug effects
Skin
/ drug effects
Skin Pigmentation
/ drug effects
Tissue Culture Techniques
Trypsin
/ metabolism
alpha-MSH
/ pharmacology
ERK
MITF degradation
isoliquiritigenin
melanogenesis
melanosome transport
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
27
06
2019
revised:
05
11
2019
accepted:
25
11
2019
pubmed:
1
12
2019
medline:
16
6
2021
entrez:
1
12
2019
Statut:
ppublish
Résumé
Isoliquiritigenin (ISL), a flavonoid component from the hydrolysis products of licorice root. It has been reported that ISL inhibited melanogenesis by suppressing the tyrosinase activity in human melanocytes. Recently, ISL was found to induce melanin degradation in human epidermal keratinocytes. However, the role of ISL in pigmentation is not fully understood. In the current study, we aimed to investigate the effects of ISL on pigmentation, and further explored the underlying mechanism. Our results suggested that ISL suppressed basal and α-MSH-, ACTH- and UV-induced melanin synthesis, in addition to inhibiting melanocyte dendricity and melanosome transport. ISL played these roles mainly by activating the extracellular signal-regulated protein kinase pathway. Once activated, it induced microphthalmia-associated transcription factor degradation and decreased the expression of tyrosinase, TRP-1, DCT, Rab27a and Cdc42, finally inhibited melanogenesis, melanocyte dendricity and melanosome transport. Our findings suggested that ISL exhibited no cytotoxicity in our research, it may prove quite useful as a safer natural skin-whitening agent.
Substances chimiques
Chalcones
0
Enzyme Inhibitors
0
Melanins
0
Microphthalmia-Associated Transcription Factor
0
alpha-MSH
581-05-5
Adrenocorticotropic Hormone
9002-60-2
isoliquiritigenin
B9CTI9GB8F
Monophenol Monooxygenase
EC 1.14.18.1
PRSS1 protein, human
EC 3.4.21.4
Trypsin
EC 3.4.21.4
Intramolecular Oxidoreductases
EC 5.3.-
dopachrome isomerase
EC 5.3.3.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-157Subventions
Organisme : The Fund of Changzhou Sci&Tech Program
ID : CJ20180007
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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