The role of neutrophils in neuro-immune modulation.
Adrenoceptors
Neuroimmunology
Neuroimmunomodulation
Neuroinflammation
Neutrophil
Nicotinic receptors
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
06
09
2019
revised:
07
11
2019
accepted:
27
11
2019
pubmed:
2
12
2019
medline:
6
1
2021
entrez:
2
12
2019
Statut:
ppublish
Résumé
Neutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injury. However, these cells can also induce overzealous responses and cause tissue damage. Although the role of neutrophils activating the immune system is well established, only recently their critical implications in neuro-immune interactions are becoming more relevant. Here, we review several aspects of neutrophils in the bidirectional regulation between the nervous and immune systems. First, the role of neutrophils as a diffuse source of acetylcholine and catecholamines is controversial as well as the effects of these neurotransmitters in neutrophil's functions. Second, neutrophils contribute for the activation and sensitization of sensory neurons, and thereby, in events of nociception and pain. In addition, nociceptor activation promotes an axon reflex triggering a local release of neural mediators and provoking neutrophil activation. Third, the recruitment of neutrophils in inflammatory responses in the nervous system suggests these immune cells as innovative targets in the treatment of central infectious, neurological and neurodegenerative disorders. Multidisciplinary studies involving immunologists and neuroscientists are required to define the role of the neurons-neutrophils communication in the pathophysiology of infectious, inflammatory, and neurological disorders.
Identifiants
pubmed: 31786317
pii: S1043-6618(19)31808-0
doi: 10.1016/j.phrs.2019.104580
pmc: PMC7023896
mid: NIHMS1556095
pii:
doi:
Substances chimiques
Neurotransmitter Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104580Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114180
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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