Increased inflammasome activity in markedly ill psychiatric patients: An explorative study.
Adolescent
Adult
Biomarkers
/ blood
Case-Control Studies
Caspase 1
/ blood
Child
Female
Humans
Inflammasomes
/ blood
Interleukin 1 Receptor Antagonist Protein
/ blood
Male
Mental Disorders
/ blood
Middle Aged
NLR Family, Pyrin Domain-Containing 3 Protein
/ blood
Severity of Illness Index
Young Adult
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
14
08
2019
revised:
20
11
2019
accepted:
25
11
2019
pubmed:
2
12
2019
medline:
10
7
2020
entrez:
2
12
2019
Statut:
ppublish
Résumé
The aim of this study was to investigate inflammatory perturbations in 40 patients with severe and complex psychiatric disorders by studying the activity of the NLRP3 inflammasome, with a trans-diagnostic approach. Gene expression of CASP1, NLRP3, PYCARD, IL1B, IL1RN, TNF showed a significant increase in the patient group compared to a matched control group. Plasma levels of IL1Ra, IL-18, TNF, IL-6 and CRP were increased in the patient group. Within the patient group, increased gene expression of inflammatory markers correlated with increased disease severity. The findings support the inflammation hypothesis for markedly ill psychiatric patients across diagnostic groups.
Identifiants
pubmed: 31786499
pii: S0165-5728(19)30416-3
doi: 10.1016/j.jneuroim.2019.577119
pii:
doi:
Substances chimiques
Biomarkers
0
IL1RN protein, human
0
Inflammasomes
0
Interleukin 1 Receptor Antagonist Protein
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
NLRP3 protein, human
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577119Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.