questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines et peptides de signalisation intracellulaire
Protéines régulatrices de l'apoptose
Caspases
Caspases initiatrices
Caspase-1
Caspase-1 : Questions médicales fréquentes
Diagnostic
5
Interleukines
Biomarqueurs
Symptômes
5
Maladies auto-immunes
Goutte
Symptômes neurologiques
Caspases
Prévention
5
Prévention
Mode de vie sain
Alimentation
Antioxydants
Traitements
5
Inhibiteurs
Antagonistes de l'IL-1
Anti-inflammatoires
Caspases
Thérapie génique
Caspases
Plantes médicinales
Inflammation
Complications
5
Maladies auto-immunes
Complications
Maladie d'Alzheimer
Neurodégénératives
Inflammation chronique
Maladies cardiovasculaires
Diabète de type 2
Inflammation
Facteurs de risque
5
Mode de vie sédentaire
Inflammation
Syndrome métabolique
Caspases
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer la caspase-1 ?",
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"@type": "Question",
"name": "Quels biomarqueurs sont associés à la caspase-1 ?",
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"@type": "Question",
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"name": "Quels signes cliniques sont associés à la caspase-1 ?",
"position": 8,
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}
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{
"@type": "Question",
"name": "La douleur est-elle un symptôme de l'activation de la caspase-1 ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, la douleur est souvent présente en raison de l'inflammation causée par la caspase-1."
}
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{
"@type": "Question",
"name": "Peut-on observer des symptômes neurologiques ?",
"position": 10,
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"text": "Oui, des symptômes neurologiques peuvent apparaître dans des conditions inflammatoires liées à la caspase-1."
}
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{
"@type": "Question",
"name": "Comment prévenir l'activation de la caspase-1 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un mode de vie sain, avec une alimentation équilibrée et de l'exercice, peut aider."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il la caspase-1 ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, le stress chronique peut exacerber l'inflammation et activer la caspase-1."
}
},
{
"@type": "Question",
"name": "Les vaccinations aident-elles à prévenir l'activation ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent réduire le risque d'infections qui activent la caspase-1."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en antioxydants peut aider à moduler l'inflammation et la caspase-1."
}
},
{
"@type": "Question",
"name": "L'exercice physique est-il bénéfique ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut réduire l'inflammation et l'activation de la caspase-1."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent la caspase-1 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de la caspase-1, comme les antagonistes de l'IL-1, sont utilisés en thérapie."
}
},
{
"@type": "Question",
"name": "Les anti-inflammatoires aident-ils contre la caspase-1 ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les anti-inflammatoires non stéroïdiens peuvent réduire l'inflammation liée à la caspase-1."
}
},
{
"@type": "Question",
"name": "La thérapie génique peut-elle cibler la caspase-1 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des approches de thérapie génique sont explorées pour moduler l'expression de la caspase-1."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont utilisés pour inhiber la caspase-1 ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme le canakinumab, un inhibiteur de l'IL-1β, ciblent indirectement la caspase-1."
}
},
{
"@type": "Question",
"name": "Les traitements naturels peuvent-ils aider ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines plantes médicinales ont montré des effets anti-inflammatoires pouvant influencer la caspase-1."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la caspase-1 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des maladies auto-immunes et des troubles inflammatoires peuvent survenir."
}
},
{
"@type": "Question",
"name": "La caspase-1 est-elle liée à des cancers ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activation anormale de la caspase-1 est associée à certains types de cancers."
}
},
{
"@type": "Question",
"name": "Peut-elle causer des maladies neurodégénératives ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'activation de la caspase-1 est impliquée dans des maladies comme la maladie d'Alzheimer."
}
},
{
"@type": "Question",
"name": "Quels risques pour la santé sont associés ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des risques comme l'inflammation chronique et les maladies cardiovasculaires peuvent être augmentés."
}
},
{
"@type": "Question",
"name": "La caspase-1 influence-t-elle le diabète ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'activation de la caspase-1 est liée à l'inflammation dans le diabète de type 2."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'activation de la caspase-1 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme l'obésité, le tabagisme et le stress peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la caspase-1 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement est associé à une augmentation de l'activation de la caspase-1."
}
},
{
"@type": "Question",
"name": "Les infections sont-elles un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections peuvent déclencher l'activation de la caspase-1 et l'inflammation."
}
},
{
"@type": "Question",
"name": "Le mode de vie sédentaire est-il un risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire peut contribuer à l'inflammation et à l'activation de la caspase-1."
}
},
{
"@type": "Question",
"name": "Les maladies métaboliques augmentent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le syndrome métabolique sont liées à une activation accrue de la caspase-1."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 22/12/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Integrative Immunobiology; Molecular Genetics and Microbiology; Pathology; and Cell Biology, Duke University School of Medicine, Durham, United States.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
RIKEN BioResource Research Center, Ibaraki, Japan.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Institute for Frontier Science Initiative (InFiniti), Kanazawa University, Kanazawa, Japan.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Departamento de Química Física, Universitat de Valencia, 46100 Burjassot, Spain.
Instituto de Materiales Avanzados, Universitat Jaume I, 12071 Castelló, Spain.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Departamento de Química Física, Universitat de Valencia, 46100 Burjassot, Spain.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Departamento de Química Física, Universitat de Valencia, 46100 Burjassot, Spain.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Department of Integrative Immunobiology; Molecular Genetics and Microbiology; Pathology; and Cell Biology, Duke University School of Medicine, Durham, United States.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Department of Integrative Immunobiology; Molecular Genetics and Microbiology; Pathology; and Cell Biology, Duke University School of Medicine, Durham, United States.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, United States.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Duke University School of Medicine.
National Institutes of Health University of North Carolina at Chapel Hill.
Departments of: Integrative Immunobiology; Molecular Genetics and Microbiology; Cell Biology; Pathology; Durham, NC, USA.
Department of Microbiology and Immunology; Chapel Hill, NC, USA.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. messidrm19@gmail.com.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
National Reference Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Department of Medical Microbiology & Immunology, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of America.
Publications dans "Caspase-1" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208; and.
Publications dans "Caspase-1" :
Macrophage pyroptosis mediates vascular inflammation and atherosclerosis (AS). Hydrogen sulfide (H2S) exerts a protective role in preventing inflammation and AS. However, its molecular mechanisms of r...
Caspase-1 is a crucial component in the inflammasome activation cascade. This study evaluated the potential of serum caspase-1 level as an inflammatory biomarker in patients with adult-onset Still's d...
The study included 51 consecutive patients diagnosed with AOSD based on the Yamaguchi criteria, 66 patients with rheumatoid arthritis (RA) as disease control, and 36 healthy controls (HCs). Serum casp...
Patients with AOSD had significantly increased serum caspase-1 levels versus patients with RA (p < 0.001) and HCs (p < 0.001). Additionally, serum caspase-1 demonstrated significant positive correlati...
Caspase-1 is a useful biomarker for AOSD diagnosis and monitoring. Caspase-1 activation could be correlated with the inflammatory component of AOSD, specifically through proinflammatory cytokine induc...
Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart failure development through its mediating role in oxidative stress. This study w...
AC16 cells were treated with 2 µmol/L of doxorubicin (DOX) for 12, 24, and 48 h to construct a heart failure model. DUOX1 overexpression and silencing in AC16 cell were established. DUOX1 expression w...
Increased DUOX1 expression levels were observed after DOX treatment for 24 h in AC16 cells. DUOX1 silencing inhibited DOX-induced pyroptosis and ROS production. The release of IL-1β, IL-18, and lactat...
These results suggest that DUOX1-derived genotoxicity could promote heart failure development. In the process, oxidative stress and pyroptosis may be involved in the regulation of DUOX1 in heart failu...
Gestational diabetes mellitus (GDM), a common complication of pregnancy, is risky for both mother and fetus. Previous studies about TP53-induced glycolysis and apoptosis regulator (TIGAR) focused on t...
Utilizing HG exposure, we explored the role of TIGAR in oxidative stress limitation, excessive inflammatory toxicity defense, and pyroptosis prevention....
TIGAR was up-regulated...
Taken together, our results uncovered that, as the upstream event of TIGAR deficiency-induced inflammation, pyroptosis is stimulated by ROS accumulation through NLRP3-ASC inflammasome....
Schizophrenia (SCZ) is a chronic, highly relapsing, severe mental disorder with an unclear etiology. Cytokine-mediated neuroimmune abnormalities have been repeatedly revealed. IL-1β was reported to pl...
Caspase-1 is a critical mediator of the inflammatory process by activating various pro-inflammatory cytokines such as pro-IL-1β, IL-18 and IL-33. Uncontrolled activation of caspase-1 leads to various ...
We investigated the potential involvement of pyroptosis, a proinflammatory form of regulated cell death, in rheumatoid arthritis (RA). Synovial fluid, synovial tissues and/or serum were compared among...
JieZe-1 (JZ-1), a Chinese herbal prescription, has an obvious effect on genital herpes, which is mainly caused by herpes simplex virus type 2 (HSV-2). Our study aimed to address whether HSV-2 induces ...
HSV-2-infected VK2/E6E7 cells and culture supernate were harvested at different time points after the infection. Cells were co-treated with HSV-2 and penciclovir (0.078125 mg/mL) or caspase-1 inhibito...
HSV-2 induced pyroptosis of VK2/E6E7 cells, with the most significant increase observed 24 h after the infection. JZ-1 effectively inhibited HSV-2 (the 50% inhibitory concentration = 1.709 mg/mL), wit...
JZ-1 exerts an excellent anti-HSV-2 effect in VK2/E6E7 cells, and it inhibits caspase-1-dependent pyroptosis induced by HSV-2 infection. These data enrich our understanding of the pathologic basis of ...
Transport and Golgi Organization protein 1 (TANGO1) is a protein that regulates the export of procollagen from the endoplasmic reticulum and has a role in the organization of exit sites for general pr...
SSc (n = 15) and healthy (n = 12) primary fibroblast lung cell lines were investigated for the expression of TANGO1. Histologic analyses for TANGO1 were performed on lung biopsy samples (n = 12 SSc pa...
SSc fibroblasts showed increased expression of TANGO1 protein in cultured fibroblasts. TANGO1 colocalizes with α-smooth muscle actin (α-SMA)-positive cells in SSc lung tissue and is highly up-regulate...
TANGO1 is markedly increased in SSc fibroblasts and was found to be elevated in lung tissue in association with α-SMA-positive cells. TANGO1 expression is driven by inflammasome-dependent caspase 1 ac...
Pyroptosis is a gasdermin-mediated pro-inflammatory form of programmed cell death (PCD). Tumor necrosis factor-ɑ (TNF-ɑ) is an inflammatory cytokine, and some studies have shown that TNF-ɑ can cause p...