Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System.
Hb Phnom Penh
HbA1c
high performance liquid chromatography
variant hemoglobin
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Mar 2020
15 Mar 2020
Historique:
pubmed:
4
12
2019
medline:
24
9
2020
entrez:
3
12
2019
Statut:
ppublish
Résumé
We herein report a 50-year-old Chinese woman with Hb Phnom Penh (α117Phe-Ile-α118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown) were observed. Therefore, the patient was refereed to our hospital; the oral glucose tolerance test showed normal glucose tolerance. The HbA1c values measured by an enzymatic assay, immunoassay, and affinity assay, as well as most HPLC assays were within the reference range, whereas those measured by the Tosoh HPLC systems were high.
Identifiants
pubmed: 31787693
doi: 10.2169/internalmedicine.3306-19
pmc: PMC7118387
doi:
Substances chimiques
Glycated Hemoglobin A
0
Hemoglobins, Abnormal
0
hemoglobin Phnom Penh
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
805-809Références
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