Anti-C1q Antibodies as Occurring in Systemic Lupus Erythematosus Could Be Induced by an Epstein-Barr Virus-Derived Antigenic Site.
A08 epitope
C1q deficient mice
EBNA-1
Epstein-Barr virus
anti-C1q antibody
autoimmunity
molecular mimicry
systemic lupus erythematosus
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
05
2019
accepted:
21
10
2019
entrez:
3
12
2019
pubmed:
4
12
2019
medline:
4
11
2020
Statut:
epublish
Résumé
Previous infection with Epstein-Barr virus (EBV) is believed to trigger autoimmunity and to drive autoantibody generation as occurring in patients with systemic lupus erythematosus (SLE). Complement C1q and autoantibodies targeting it (anti-C1q) are also considered to be involved in the pathogenesis of SLE, independently of the impact of environmental insults. Still, the circumstances under which these autoantibodies arise remain elusive. By studying a major antigenic site of C1q targeted by anti-C1q (A08), we aimed to determine environmental factors and possible mechanisms leading to the development of anti-C1q. First, we determined antigenic residues of A08 that were critical for the binding of anti-C1q; importantly, we found the binding to depend on amino-acid-identity. Anti-C1q of SLE patients targeting these critical antigenic residues specifically cross-reacted with the EBV-related EBNA-1 (Epstein-Barr virus nuclear antigen 1)-derived peptide EBNA348. In a cohort of 180 SLE patients we confirmed that patients that were seropositive for EBV and recognized the EBNA348 peptide had increased levels of anti-A08 and anti-C1q, respectively. The correlation of anti-EBNA348 with anti-A08 levels was stronger in SLE patients than in matched healthy controls. Finally, EBNA348 peptide-immunization of C1q
Identifiants
pubmed: 31787984
doi: 10.3389/fimmu.2019.02619
pmc: PMC6853867
doi:
Substances chimiques
Autoantibodies
0
Epstein-Barr Virus Nuclear Antigens
0
Complement C1q
80295-33-6
EBV-encoded nuclear antigen 1
O5GA75RST7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2619Informations de copyright
Copyright © 2019 Csorba, Schirmbeck, Tuncer, Ribi, Roux-Lombard, Chizzolini, Huynh-Do, Vanhecke and Trendelenburg.
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