Benzothiazole derivatives as anticancer agents.

Antineoplastic Agents / chemical synthesis Benzothiazoles / chemical synthesis Cell Line Cell Proliferation / drug effects Dose-Response Relationship, Drug Humans Molecular Structure Neoplasms / drug therapy Structure-Activity Relationship
Benzothiazole anticancer agent carbonic anhydrase inhibitor drug targets scaffold

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2020
Historique:
entrez: 3 12 2019
pubmed: 4 12 2019
medline: 16 1 2020
Statut: ppublish

Résumé

Benzothiazole (BTA) belongs to the heterocyclic class of bicyclic compounds. BTA derivatives possesses broad spectrum biological activities such as anticancer, antioxidant, anti-inflammatory, anti-tumour, antiviral, antibacterial, anti-proliferative, anti-diabetic, anti-convulsant, analgesic, anti-tubercular, antimalarial, anti-leishmanial, anti-histaminic and anti-fungal among others. The BTA scaffolds showed a crucial role in the inhibition of the metalloenzyme carbonic anhydrase (CA). In this review an extensive literature survey over the last decade discloses the role of BTA derivatives mainly as anticancer agents. Such compounds are effective against various types of cancer cell lines through a multitude of mechanisms, some of which are poorly studied or understood. The inhibition of tumour associated CAs by BTA derivatives is on the other hand better investigated and such compounds may serve as anticancer leads for the development of agents effective against hypoxic tumours.

Identifiants

DOI: 10.1080/14756366.2019.1698036 PMID: 31790602 PMC: PMC6896476
pubmed: 31790602
doi: 10.1080/14756366.2019.1698036
pmc: PMC6896476
doi:

Substances chimiques

Antineoplastic Agents 0
Benzothiazoles 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

265-279

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Auteurs

Ali Irfan (A)

Department of Chemistry, University of Lahore, Sargodha, Pakistan.

Fozia Batool (F)

Department of Chemistry, University of Lahore, Sargodha, Pakistan.

Syeda Andleeb Zahra Naqvi (SA)

Department of Chemistry, University of Lahore, Sargodha, Pakistan.

Amjad Islam (A)

College of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou, P.R. China.

Sameh M Osman (SM)

Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

Alessio Nocentini (A)

NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino (Firenze), Italy.

Siham A Alissa (SA)

Chemistry Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Claudiu T Supuran (CT)

NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino (Firenze), Italy.
ORCID: 0000-0003-4262-0323

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzothiazoles › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Tumeurs › Benzothiazole derivatives as anticancer agents.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Benzothiazole derivatives as anticancer agents.