CD138-negative plasma cell myeloma: a diagnostic challenge and a unique entity.
haematology (incl blood transfusion)
immunology
malignant and benign haematology
pathology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
01 Dec 2019
01 Dec 2019
Historique:
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
25
4
2020
Statut:
epublish
Résumé
Plasma cell neoplasms may exhibit variations in morphology and immunophenotype, which can mimic mature B-cell lymphoproliferative disorders and pose diagnostic challenges. This case illustrates a rare entity of plasma cell myeloma, where the entire plasma cell population exhibited lymphoid morphology, negativity for CD138, positivity for CD20 and cyclin D1, and positive fluorescence in situ hybridisation for t(11;14) and del(17 p), mimicking a mature B-cell lymphoproliferative disorder, in particular mantle cell lymphoma. In this case, a careful analysis of flow cytometry gating strategies and use of other ancillary tests were keys for correct diagnosis. In addition to the diagnostic implications due to its rarity, CD138-negative plasma cell myeloma may represent a unique entity, which is associated with 'stem cell'-like clonogenic properties, more aggressive clinical behaviour and resistance to chemotherapy.
Identifiants
pubmed: 31791993
pii: 12/11/e232233
doi: 10.1136/bcr-2019-232233
pmc: PMC6887473
pii:
doi:
Substances chimiques
Antigens, CD20
0
CCND1 protein, human
0
SDC1 protein, human
0
Syndecan-1
0
Cyclin D1
136601-57-5
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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