Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa.
Animals
Anti-HIV Agents
/ administration & dosage
Anti-Infective Agents, Local
/ pharmacology
CD4 Antigens
/ metabolism
Cadherins
/ metabolism
Cell Count
Epithelial Cells
/ drug effects
Intestinal Mucosa
/ cytology
Lectins
/ administration & dosage
Macaca mulatta
Plant Lectins
/ administration & dosage
Recombinant Proteins
Rectum
/ cytology
Time Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 12 2019
02 12 2019
Historique:
received:
16
05
2019
accepted:
12
11
2019
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
18
12
2020
Statut:
epublish
Résumé
Natural-product derived lectins can function as potent viral inhibitors with minimal toxicity as shown in vitro and in small animal models. We here assessed the effect of rectal application of an anti-HIV lectin-based microbicide Q-Griffithsin (Q-GRFT) in rectal tissue samples from rhesus macaques. E-cadherin
Identifiants
pubmed: 31792342
doi: 10.1038/s41598-019-54493-4
pii: 10.1038/s41598-019-54493-4
pmc: PMC6889265
doi:
Substances chimiques
Anti-HIV Agents
0
Anti-Infective Agents, Local
0
CD4 Antigens
0
Cadherins
0
Lectins
0
Plant Lectins
0
Recombinant Proteins
0
q-griffithsin
0
griffithsin protein, Griffithsia
Z8PX5UX50U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18120Subventions
Organisme : NIAID NIH HHS
ID : U19 AI113182
Pays : United States
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