Genetic investigation of equine recurrent uveitis in Appaloosa horses.
Appaloosa
depigmentation
genome-wide association study
horse
recurrent uveitis
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
accepted:
06
11
2019
pubmed:
4
12
2019
medline:
14
2
2020
entrez:
4
12
2019
Statut:
ppublish
Résumé
Equine recurrent uveitis (ERU) is characterized by intraocular inflammation that often leads to blindness in horses. Appaloosas are more likely than any other breed to develop insidious ERU, distinguished by low-grade chronic intraocular inflammation, suggesting a genetic predisposition. Appaloosas are known for their white coat spotting patterns caused by the leopard complex spotting allele (LP) and the modifier PATN1. A marker linked to LP on ECA1 and markers near MHC on ECA20 were previously associated with increased ERU risk. This study aims to further investigate these loci and identify additional genetic risk factors. A GWAS was performed using the Illumina Equine SNP70 BeadChip in 91 horses. Additive mixed model approaches were used to correct for relatedness. Although they do not reach a strict Bonferroni genome-wide significance threshold, two SNPs on ECA1 and one SNP each on ECA12 and ECA29 were among the highest ranking SNPs and thus warranted further analysis (P = 1.20 × 10
Substances chimiques
TRPM Cation Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111-116Subventions
Organisme : NIH HHS
ID : F30 OD023369
Pays : United States
Organisme : Morris Animal Foundation
ID : D16EQ-028
Organisme : Townsend Equine Health Research Fund (TEHRF)
Informations de copyright
© 2019 Stichting International Foundation for Animal Genetics.
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