Neural correlates of altered insight in frontotemporal dementia: a systematic review.

Amyotrophic Lateral Sclerosis / diagnostic imaging Aphasia, Primary Progressive / diagnostic imaging Brain / diagnostic imaging Frontotemporal Dementia / diagnostic imaging Humans Magnetic Resonance Imaging Metacognition Positron-Emission Tomography Primary Progressive Nonfluent Aphasia / diagnostic imaging Self Concept Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed
Frontotemporal dementia Insight Neural correlates

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2019
Historique:
received: 06 06 2019
revised: 14 09 2019
accepted: 03 11 2019
pubmed: 5 12 2019
medline: 22 9 2020
entrez: 5 12 2019
Statut: ppublish

Résumé

Altered insight into disease or specific symptoms is a prominent clinical feature of frontotemporal dementia (FTD). Understanding the neural bases of insight is crucial to help improve FTD diagnosis, classification and management. A systematic review to explore the neural correlates of altered insight in FTD and associated syndromes was conducted. Insight was fractionated to examine whether altered insight into different neuropsychological/behavioural objects is underpinned by different or compatible neural correlates. 6 databases (Medline, Embase, PsycINFO, Web of Science, BIOSIS and ProQuest Dissertations & Theses Global) were interrogated between 1980 and August 2019. 15 relevant papers were found out of 660 titles screened. The studies included suggest that different objects of altered insight are associated with distinctive brain areas in FTD. For example, disease unawareness appears to predominantly correlate with right frontal involvement. In contrast, altered insight into social cognition potentially involves, in addition to frontal areas, the temporal gyrus, insula, parahippocampus and amygdala. Impaired insight into memory problems appears to be related to the frontal lobes, postcentral gyrus, parietal cortex and posterior cingulate. These results reflect to a certain extent those observed in other neurodegenerative conditions like Alzheimer's disease (AD) and also other brain disorders. Nevertheless, they should be cautiously interpreted due to variability in the methodological aspects used to reach those conclusions. Future work should triangulate different insight assessment approaches and brain imaging techniques to increase the understanding of this highly relevant clinical phenomenon in dementia.

Identifiants

DOI: 10.1016/j.nicl.2019.102066 PMID: 31795052 PMC: PMC6889795
pubmed: 31795052
pii: S2213-1582(19)30413-9
doi: 10.1016/j.nicl.2019.102066
pmc: PMC6889795
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102066

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Carlos Muñoz-Neira (C)

Research into Memory, Brain sciences and dementia Group (ReMemBr Group), Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, UK; Clinical Research and Imaging Centre (CRICBristol), Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, UK. Electronic address: carlos.munoz@bristol.ac.uk.

Andrea Tedde (A)

Department of Clinical and Experimental Medicine, Faculty of Medicine and Surgery, University of Sassari, Italy.

Elizabeth Coulthard (E)

Research into Memory, Brain sciences and dementia Group (ReMemBr Group), Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, UK; Clinical Research and Imaging Centre (CRICBristol), Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, UK.

N Jade Thai (NJ)

Clinical Research and Imaging Centre (CRICBristol), Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, UK.

Catherine Pennington (C)

Research into Memory, Brain sciences and dementia Group (ReMemBr Group), Translational Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, UK; Centre for Dementia Prevention, University of Edinburgh, UK.

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Neural correlates of altered insight in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Aphasie progressive primaire › Neural correlates of altered insight in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Neural correlates of altered insight in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Démence frontotemporale › Neural correlates of altered insight in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neural correlates of altered insight in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Neural correlates of altered insight in...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Métacognition › Neural correlates of altered insight in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Neural correlates of altered insight in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Aphasie primaire progressive non fluente › Neural correlates of altered insight in...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Personnalité › Développement de la personnalité › Concept du soi › Neural correlates of altered insight in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Neural correlates of altered insight in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Neural correlates of altered insight in...