Risk of Rapid Kidney Function Decline, All-Cause Mortality, and Major Cardiovascular Events in Nonalbuminuric Chronic Kidney Disease in Type 2 Diabetes.
Adult
Aged
Aged, 80 and over
Albuminuria
/ complications
Cardiovascular Diseases
/ etiology
Cause of Death
Diabetes Mellitus, Type 2
/ complications
Diabetic Angiopathies
/ complications
Diabetic Nephropathies
/ mortality
Disease Progression
Female
Glomerular Filtration Rate
Humans
Kidney Failure, Chronic
/ mortality
Male
Middle Aged
Renal Insufficiency, Chronic
/ complications
Risk Factors
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
22
07
2019
accepted:
04
10
2019
pubmed:
5
12
2019
medline:
15
9
2020
entrez:
5
12
2019
Statut:
ppublish
Résumé
We aimed to investigate the rate of progression of nonalbuminuric chronic kidney disease (CKD) to end-stage kidney disease (ESKD) or death or major cardiovascular events (MACE) compared with albuminuric and nonalbuminuric phenotypes. We included 10,185 participants with type 2 diabetes enrolled in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. Based on baseline albuminuria and estimated glomerular filtration rate (eGFR), participants were classified as having no kidney disease (no CKD), albuminuria only (albuminuric non-CKD), reduced eGFR only (nonalbuminuric CKD), or both albuminuria and reduced eGFR (albuminuric CKD). The rate of eGFR decline and hazard ratios (HRs) for ESKD or death or MACE were calculated. For individuals with no CKD and those with nonalbuminuric CKD, the rates of eGFR decline were -1.31 and -0.60 mL/min/year, respectively ( Those with nonalbuminuric CKD showed a slower rate of decline in eGFR than did any other group; however, these individuals still carry a greater risk for death and MACE than do those with no CKD.
Identifiants
pubmed: 31796570
pii: dc19-1438
doi: 10.2337/dc19-1438
pmc: PMC7411281
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
122-129Informations de copyright
© 2019 by the American Diabetes Association.
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