Prenatal Glucocorticoid Exposure Results in Changes in Gene Transcription and DNA Methylation in the Female Juvenile Guinea Pig Hippocampus Across Three Generations.
Animals
DNA Methylation
/ drug effects
Disease Models, Animal
Epigenesis, Genetic
/ drug effects
Female
Glucocorticoids
/ adverse effects
Guinea Pigs
Hippocampus
/ drug effects
Humans
Inheritance Patterns
/ drug effects
Male
Maternal Exposure
/ adverse effects
Pregnancy
Premature Birth
/ prevention & control
Prenatal Exposure Delayed Effects
/ chemically induced
Receptors, Glucocorticoid
/ metabolism
Receptors, Mineralocorticoid
/ metabolism
Transcription, Genetic
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
received:
10
06
2019
accepted:
13
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Synthetic glucocorticoids (sGC) are administered to women at risk for pre-term delivery, to mature the fetal lung and decrease neonatal morbidity. sGC also profoundly affect the fetal brain. The hippocampus expresses high levels of glucocorticoid (GR) and mineralocorticoid receptor (MR), and its development is affected by elevated fetal glucocorticoid levels. Antenatal sGC results in neuroendocrine and behavioral changes that persist in three generations of female guinea pig offspring of the paternal lineage. We hypothesized that antenatal sGC results in transgenerational changes in gene expression that correlate with changes in DNA methylation. We used RNASeq and capture probe bisulfite sequencing to investigate the transcriptomic and epigenomic effects of antenatal sGC exposure in the hippocampus of three generations of juvenile female offspring from the paternal lineage. Antenatal sGC exposure (F
Identifiants
pubmed: 31796763
doi: 10.1038/s41598-019-54456-9
pii: 10.1038/s41598-019-54456-9
pmc: PMC6890750
doi:
Substances chimiques
Glucocorticoids
0
Receptors, Glucocorticoid
0
Receptors, Mineralocorticoid
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18211Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : FDN-148368
Pays : International
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