Gender differences in the effect of diabetes mellitus and its treatment on osteoarthritic pain.
Aged
Arthralgia
/ complications
Cohort Studies
Diabetes Mellitus, Type 2
/ complications
Female
Hip Joint
Humans
Hypoglycemic Agents
/ therapeutic use
Knee Joint
Male
Middle Aged
Osteoarthritis, Knee
/ complications
Pain Measurement
Risk Factors
Severity of Illness Index
Sex Characteristics
Sex Factors
adult diabetes
pain
rheumatologic/musculoskeletal disease
risk factors
Journal
BMJ open diabetes research & care
ISSN: 2052-4897
Titre abrégé: BMJ Open Diabetes Res Care
Pays: England
ID NLM: 101641391
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
07
2019
revised:
13
09
2019
accepted:
09
10
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
1
9
2020
Statut:
epublish
Résumé
(1) To investigate differences in pain severity and its distribution between patients with and without diabetes mellitus (DM) in a population with advanced osteoarthritis (OA). (2) To explore the role of medication used for diabetes in these associations. This is a hospital-based cohort study of patients with advanced OA requiring total joint arthroplasty. Interviews and electronic records included: age, gender, occupation, DM (including medication and duration), analgesics used, anthropometry, joints affected by pain and disease duration. Joint pain was scored by the patients using numerical rating scale. Pain severity score was calculated by adding the number of joints affected by pain and the maximum pain score. All analyses were adjusted and/or stratified by gender, age and body mass index. In total, 489 patients with painful OA were included. From those, 139 patients had DM (30% males and 28% females, p=0.03). Pain severity, principally the number of joints affected by pain, and analgesic consumption, was higher in males with diabetes compared with males without diabetes (p=0.012 and OR=3.03; 95% CI 1.24 to 7.36, p=0.015, respectively). These associations were not significant in females (p=0.41 and p=0.66). Pain was more severe in males using insulin versus those who did not (p=0.025). Male subjects with diabetes had higher odds of hand pain or knee and hand pain compared with males without diabetes (OR=3.7, 95% CI 1.15 to 12; p=0.028 and OR=5.54; 95% CI 1.43 to 21.5, p=0.013, respectively). Males with diabetes, especially those who require insulin, have more severe joint pain and consume more analgesics than males without diabetes or those who have DM and use other DM medication.
Identifiants
pubmed: 31798897
doi: 10.1136/bmjdrc-2019-000736
pii: bmjdrc-2019-000736
pmc: PMC6861009
doi:
Substances chimiques
Hypoglycemic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e000736Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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