The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family.
KSHV
miR-15/16
microRNA
tumor virus
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
received:
10
06
2019
revised:
07
10
2019
accepted:
01
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
29
9
2020
Statut:
ppublish
Résumé
Many tumor viruses encode oncogenes of cellular origin. Here, we report an oncoviral mimic of a cellular tumor suppressor. The Kaposi's sarcoma-associated herpesvirus (KSHV) microRNA (miRNA) miR-K6-5p shares sequence similarity to the tumor-suppressive cellular miR-15/16 miRNA family. We show that miR-K6-5p inhibits cell cycle progression, a hallmark function of miR-16. miR-K6-5p regulates conserved miR-15/16 family miRNA targets, including many cell cycle regulators. Inhibition of miR-K6-5p in KSHV-transformed B cells confers a significant growth advantage. Altogether, our data show that KSHV encodes a functional mimic of miR-15/16 family miRNAs. While it is exceedingly well established that oncogenic viruses encode oncogenes of cellular origin, this is an unusual example of an oncogenic virus that encodes a viral mimic of a cellular tumor suppressor. Encoding a tumor-suppressive miRNA could help KSHV balance viral oncogene expression and thereby avoid severe pathogenesis in the healthy host.
Identifiants
pubmed: 31801064
pii: S2211-1247(19)31476-7
doi: 10.1016/j.celrep.2019.11.005
pmc: PMC6939447
mid: NIHMS1545828
pii:
doi:
Substances chimiques
MIRN15 microRNA, human
0
MIRN16 microRNA, human
0
MicroRNAs
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2961-2969.e6Subventions
Organisme : NCI NIH HHS
ID : R01 CA180813
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA210904
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008061
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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