The molecular landscape of ETMR at diagnosis and relapse.

DEAD-box RNA Helicases / genetics DNA Topoisomerases, Type I / genetics Humans MicroRNAs / genetics Mutation Neoplasms, Germ Cell and Embryonal / diagnosis Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases / genetics Polymorphism, Single Nucleotide RNA, Long Noncoding Recurrence Ribonuclease III / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
12 2019
Historique:
received: 21 12 2018
accepted: 16 10 2019
pubmed: 6 12 2019
medline: 3 4 2020
entrez: 6 12 2019
Statut: ppublish

Résumé

Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis

Identifiants

DOI: 10.1038/s41586-019-1815-x PMID: 31802000 PMC: PMC6908757
pubmed: 31802000
doi: 10.1038/s41586-019-1815-x
pii: 10.1038/s41586-019-1815-x
pmc: PMC6908757
mid: NIHMS1541318
doi:

Substances chimiques

MIR17HG, human 0
MicroRNAs 0
Poly(ADP-ribose) Polymerase Inhibitors 0
RNA, Long Noncoding 0
Poly(ADP-ribose) Polymerases EC 2.4.2.30
DICER1 protein, human EC 3.1.26.3
Ribonuclease III EC 3.1.26.3
DEAD-box RNA Helicases EC 3.6.4.13
DNA Topoisomerases, Type I EC 5.99.1.2
TOP1 protein, human EC 5.99.1.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

274-280

Subventions

Organisme : NIDCR NIH HHS
ID : R21 DE030603
Pays : United States
Organisme : NIEHS NIH HHS
ID : R15 ES019128
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002647
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA148724
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA054174
Pays : United States
Organisme : NIEHS NIH HHS
ID : K22 ES012264
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA152063
Pays : United States

Références

Korshunov, A. et al. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol. 128, 279–289 (2014).
pubmed: 24337497
Pfister, S. et al. Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol. 117, 457–464 (2009).
pubmed: 19057917
Li, M. et al. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 16, 533–546 (2009).
pubmed: 19962671 pmcid: 3431561
Kleinman, C. L. et al. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nat. Genet. 46, 39–44 (2014).
pubmed: 24316981
Eberhart, C. G., Brat, D. J., Cohen, K. J. & Burger, P. C. Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr. Dev. Pathol. 3, 346–352 (2000).
pubmed: 10890250
Sturm, D. et al. New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 164, 1060–1072 (2016).
pubmed: 26919435 pmcid: 5139621
Capper, D. et al. DNA methylation-based classification of central nervous system tumours. Nature 555, 469–474 (2018).
pubmed: 29539639 pmcid: 29539639
Pearl, L. H., Schierz, A. C., Ward, S. E., Al-Lazikani, B. & Pearl, F. M. Therapeutic opportunities within the DNA damage response. Nat. Rev. Cancer 15, 166–180 (2015).
pubmed: 25709118
Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods 12, 453–457 (2015).
pubmed: 25822800 pmcid: 4739640
Zhong, S. et al. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature 555, 524–528 (2018).
pubmed: 29539641
Neumann, J. E. et al. A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors. Nat. Med. 23, 1191–1202 (2017).
pubmed: 28892064
Anglesio, M. S. et al. Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage. J. Pathol. 229, 400–409 (2013).
pubmed: 23132766
Gröbner, S. N. et al. The landscape of genomic alterations across childhood cancers. Nature 555, 321–327 (2018).
Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415–421 (2013).
pubmed: 23945592 pmcid: 23945592
Szikriszt, B. et al. A comprehensive survey of the mutagenic impact of common cancer cytotoxics. Genome Biol. 17, 99 (2016).
pubmed: 27161042 pmcid: 4862131
Boot, A. et al. In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors. Genome Res. 28, 654–665 (2018).
pubmed: 29632087 pmcid: 5932606
Maciejowski, J., Li, Y., Bosco, N., Campbell, P. J. & de Lange, T. Chromothripsis and kataegis induced by telomere crisis. Cell 163, 1641–1654 (2015).
pubmed: 26687355 pmcid: 4687025
Santos-Pereira, J. M. & Aguilera, A. R loops: new modulators of genome dynamics and function. Nat. Rev. Genet. 16, 583–597 (2015).
pubmed: 26370899
El Hage, A., French, S. L., Beyer, A. L. & Tollervey, D. Loss of topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev. 24, 1546–1558 (2010).
pubmed: 20634320 pmcid: 2904944
Jenjaroenpun, P., Wongsurawat, T., Yenamandra, S. P. & Kuznetsov, V. A. QmRLFS-finder: a model, web server and stand-alone tool for prediction and analysis of R-loop forming sequences. Nucleic Acids Res. 43, W527–W534 (2015).
pubmed: 25883153 pmcid: 4489302
Gorthi, A. et al. EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature 555, 387–391 (2018).
pubmed: 29513652 pmcid: 6318124
Kloosterman, W. P. et al. Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms. Cell Rep. 1, 648–655 (2012).
pubmed: 22813740
Gan, W. et al. R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes Dev. 25, 2041–2056 (2011).
pubmed: 21979917 pmcid: 3197203
Lu, W. T. et al. Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair. Nat. Commun. 9, 532 (2018).
pubmed: 29416038 pmcid: 5803274
Castel, S. E. et al. Dicer promotes transcription termination at sites of replication stress to maintain genome stability. Cell 159, 572–583 (2014).
pubmed: 25417108 pmcid: 4243041
Francia, S. et al. Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature 488, 231–235 (2012).
pubmed: 22722852 pmcid: 3442236
Schmidt, C. et al. Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients. Neuro Oncol. 19, 1607–1617 (2017).
pubmed: 28482026 pmcid: 5716199
Staker, B. L. et al. The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc. Natl Acad. Sci. USA 99, 15387–15392 (2002).
pubmed: 12426403
Das, S. K. et al. Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells. Nucleic Acids Res. 44, 8363–8375 (2016).
pubmed: 27466387 pmcid: 5041477
Bennasser, Y. et al. Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels. Nat. Struct. Mol. Biol. 18, 323–327 (2011).
pubmed: 21297638 pmcid: 3595992
Grimm, D. et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441, 537–541 (2006).
pubmed: 16724069
Schultz, K. A. P. et al. PTEN, DICER1, FH, and their associated tumor susceptibility syndromes: clinical features, genetics, and surveillance recommendations in childhood. Clin. Cancer Res. 23, e76–e82 (2017).
pubmed: 28620008
Seki, M. et al. Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma. Cancer Res. 74, 2742–2749 (2014).
pubmed: 24675358
Koelsche, C. et al. Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations. Acta Neuropathol. 136, 327–337 (2018).
pubmed: 29881993
Hovestadt, V. et al. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathol. 125, 913–916 (2013).
pubmed: 23670100 pmcid: 3661908
Spence, T. et al. A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. Neuro Oncol. 16, 62–71 (2014).
pubmed: 24311633
Sahm, F. et al. Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets. Acta Neuropathol. 131, 903–910 (2016).
pubmed: 26671409
Jones, D. T. et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 488, 100–105 (2012).
pubmed: 22832583 pmcid: 3662966
Uro-Coste, E. et al. ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors. Acta Neuropathol. 137, 175–177 (2019).
pubmed: 30446821
Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882–883 (2012).
pubmed: 22257669 pmcid: 22257669
van der Maaten, L. & Hinton, G. Visualizing data using t-SNE. J. Mach. Learn. Res. 9, 2579–2605 (2008).
Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078–2079 (2009).
pubmed: 19505943 pmcid: 19505943
Kool, M. et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell 25, 393–405 (2014).
pubmed: 24651015 pmcid: 4493053
Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
pubmed: 20601685 pmcid: 20601685
Kircher, M. et al. A general framework for estimating the relative pathogenicity of human genetic variants. Nat. Genet. 46, 310–315 (2014).
pubmed: 24487276 pmcid: 3992975
Waszak, S. M. et al. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol. 19, 785–798 (2018).
pubmed: 29753700 pmcid: 5984248
The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57–74 (2012).
pmcid: 3439153
Koboldt, D. C. et al. VarScan: variant detection in massively parallel sequencing of individual and pooled samples. Bioinformatics 25, 2283–2285 (2009).
pubmed: 19542151 pmcid: 2734323
Haradhvala, N. J. et al. Mutational strand asymmetries in cancer genomes reveal mechanisms of DNA damage and repair. Cell 164, 538–549 (2016).
pubmed: 26806129 pmcid: 4753048
Blokzijl, F., Janssen, R., van Boxtel, R. & Cuppen, E. MutationalPatterns: comprehensive genome-wide analysis of mutational processes. Genome Med. 10, 33 (2018).
pubmed: 29695279 pmcid: 5922316
Johann, P. D. et al. Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes. Cancer Cell 29, 379–393 (2016).
pubmed: 26923874
Northcott, P. A. et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature 511, 428–434 (2014).
pubmed: 4201514 pmcid: 4201514
Chen, J., Bardes, E. E., Aronow, B. J. & Jegga, A. G. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37, W305–W311 (2009).
pubmed: 19465376 pmcid: 2703978
Huang, D. W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44–57 (2009).
Wei, Q., Khan, I. K., Ding, Z., Yerneni, S. & Kihara, D. NaviGO: interactive tool for visualization and functional similarity and coherence analysis with gene ontology. BMC Bioinformatics 18, 177 (2017).
pubmed: 28320317 pmcid: 5359872
Bray, N. L., Pimentel, H., Melsted, P. & Pachter, L. Near-optimal probabilistic RNA-seq quantification. Nat. Biotechnol. 34, 525–527 (2016).
pubmed: 27043002
Hovestadt, V. et al. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature 510, 537–541 (2014).
pubmed: 24847876
Hafner, M. et al. Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods 44, 3–12 (2008).
pubmed: 18158127 pmcid: 2847350
Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).
pubmed: 3218662 pmcid: 3218662
Kozomara, A. & Griffiths-Jones, S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42, D68–D73 (2014).
pubmed: 24275495
Ramírez, F., Dündar, F., Diehl, S., Grüning, B. A. & Manke, T. deepTools: a flexible platform for exploring deep-sequencing data. Nucleic Acids Res. 42, W187–W191 (2014).
pubmed: 24799436 pmcid: 4086134
Cer, R. Z. et al. Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools. Nucleic Acids Res. 41, D94–D100 (2013).
pubmed: 23125372
Korshunov, A. et al. Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol. 120, 253–260 (2010).
pubmed: 20407781
Sanz, L. A. et al. Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals. Mol. Cell 63, 167–178 (2016).
pubmed: 27373332 pmcid: 4955522
Chou, T. C. Drug combination studies and their synergy quantification using the Chou–Talalay method. Cancer Res. 70, 440–446 (2010).
Anderson, N. D. et al. Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science 361, eaam8419 (2018).
pubmed: 30166462 pmcid: 6176908

Auteurs

Sander Lambo (S)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Susanne N Gröbner (SN)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Tobias Rausch (T)

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.

Sebastian M Waszak (SM)

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.

Christin Schmidt (C)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Aparna Gorthi (A)

Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.

July Carolina Romero (JC)

Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.

Monika Mauermann (M)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Sebastian Brabetz (S)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Sonja Krausert (S)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Ivo Buchhalter (I)

Omics IT and Data Management Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jan Koster (J)

Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.

Danny A Zwijnenburg (DA)

Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.

Martin Sill (M)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jens-Martin Hübner (JM)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Norman Mack (N)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Benjamin Schwalm (B)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Marina Ryzhova (M)

Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia.

Volker Hovestadt (V)

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Simon Papillon-Cavanagh (S)

Department of Pediatrics, McGill University Health Center, McGill University, Montreal, Quebec, Canada.

Jennifer A Chan (JA)

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.

Pablo Landgraf (P)

Department of Pediatrics, Pediatric Oncology and Hematology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Ben Ho (B)

Division of Hematology/Oncology Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

Till Milde (T)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.

Olaf Witt (O)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.

Jonas Ecker (J)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.

Felix Sahm (F)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

David Sumerauer (D)

Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.

David W Ellison (DW)

Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.

Brent A Orr (BA)

Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.

Anna Darabi (A)

Department of Clinical Sciences Lund, Section of Neurosurgery, Faculty of Medicine, Lund University, Lund, Sweden.

Christine Haberler (C)

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

Dominique Figarella-Branger (D)

Aix-Marseille University, Neurophysiopathology Institute (INP), CNRS, Marseille, France.
Department of Pathology, APHM, Marseille, France.

Pieter Wesseling (P)

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Department of Pathology, Amsterdam University Medical Centers/location VUmc, Amsterdam, The Netherlands.

Jens Schittenhelm (J)

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany.
Center for CNS Tumors, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital of Tübingen, Tübingen, Germany.

Marc Remke (M)

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.
Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Michael D Taylor (MD)

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Maria J Gil-da-Costa (MJ)

Pediatric Hematology and Oncology Division, University Hospital São João Alameda Hernani Monteiro, Porto, Portugal.

Maria Łastowska (M)

Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland.

Wiesława Grajkowska (W)

Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland.

Martin Hasselblatt (M)

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

Peter Hauser (P)

2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.

Torsten Pietsch (T)

Institute of Neuropathology, Brain Tumor Reference Center of the German Society of Neuropathology and Neuroanatomy, University of Bonn Medical Center, Bonn, Germany.

Emmanuelle Uro-Coste (E)

Department of Pathology, Toulouse University Hospital, Toulouse, France.
INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.

Franck Bourdeaut (F)

INSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Paris Sciences Lettres Research University, Curie Institute, Paris, France.

Julien Masliah-Planchon (J)

Pediatric Oncology Department, SIREDO Pediatric Oncology Centre, Curie Institute, Paris, France.
Paris Sciences et Lettres Research University, Institut Curie Hospital, Laboratory of Somatic Genetics, Paris, France.

Valérie Rigau (V)

Department of Pathology, Montpellier University Medical Center, Montpellier, France.
Institute for Neuroscience of Montpellier (INM), INSERM U1051, Montpellier University Hospital, Montpellier, France.

Sanda Alexandrescu (S)

Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Stephan Wolf (S)

Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Xiao-Nan Li (XN)

Brain Tumor Program, Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Ulrich Schüller (U)

Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
Research Institute Children's Cancer Center, Hamburg, Germany.
Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.

Matija Snuderl (M)

Department of Pathology, NYU Langone Health, New York, NY, USA.

Matthias A Karajannis (MA)

Division of Pediatric Hematology/Oncology, NYU Langone Medical Center, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, New York, NY, USA.

Felice Giangaspero (F)

Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
IRCCS Neuromed-Mediterranean Neurological Institute, Pozzilli, Italy.

Nada Jabado (N)

Department of Pediatrics, McGill University Health Center, McGill University, Montreal, Quebec, Canada.

Andreas von Deimling (A)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

David T W Jones (DTW)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jan O Korbel (JO)

European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.

Katja von Hoff (K)

Department of Pediatric Oncology/Hematology, Charité University Medicine, Berlin, Germany.
Department for Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Peter Lichter (P)

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Annie Huang (A)

Division of Hematology/Oncology Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Pediatrics, Medical Biophysics, Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Alexander J R Bishop (AJR)

Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX, USA.
Mays Cancer Center, University of Texas Health at San Antonio, San Antonio, TX, USA.

Stefan M Pfister (SM)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.

Andrey Korshunov (A)

Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Marcel Kool (M)

Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany. m.kool@dkfz.de.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.kool@dkfz.de.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. m.kool@dkfz.de.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › ADN topoisomérases de type I › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs embryonnaires et germinales › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de poly(ADP-ribose) polymérases › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › The molecular landscape of ETMR at diagnosis...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Endoribonucleases › Ribonuclease III › The molecular landscape of ETMR at diagnosis...