Click Reaction for Reversible Encapsulation of Single Yeast Cells.
cell protection
cell stability
click reaction
directed chemistry
hierarchical assembly
mesoporous materials
reversible encapsulation
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
24 12 2019
24 12 2019
Historique:
pubmed:
6
12
2019
medline:
2
9
2020
entrez:
6
12
2019
Statut:
ppublish
Résumé
Cell surface engineering is an emerging technology to encapsulate cells in order to enhance their functions. However, methods for reversible encapsulation of cells with abiotic functionalities are rare. Herein, we describe a phenylboronic acid based click reaction for encapsulation of single yeast cells using mesoporous silica nanoparticles (MSNs). This encapsulation does not impact natural growth of the cells and leads to a significant enhancement of cell survival in a variety of hostile environments. Owing to the glucose-responsiveness of the boronate ester bond between cell surface polysaccharides and B(OH)
Identifiants
pubmed: 31804798
doi: 10.1021/acsnano.9b08108
doi:
Substances chimiques
Boronic Acids
0
Silicon Dioxide
7631-86-9
benzeneboronic acid
L12H7B02G5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM